Abstract | BACKGROUND: Pu'er tea, a type of post-fermented tea made from Camellia sinensis leaves, has long been widely used in East Asian countries. It is mainly produced in southern China and is effective in preventing obesity due to its ability to break down fat. However, the effects of Pu'er tea on cognitive impairment or neuroinflammation by endotoxin have not yet been studied. PURPOSE: STUDY DESIGN: METHODS: RESULTS: First, Morris water maze (MWM) and passive avoidance (PA) tests demonstrated that oral administration of PTW effectively attenuated LPS-induced spatial memory loss and inhibited neuronal damage of mouse brains. Histopathological analysis showed that PTW repressed LPS-induced expression of the activation markers ionized calcium-binding adaptor molecule-1 (Iba-1) and glial fibrillary acidic protein (GFAP). Furthermore, PTW inhibited the expression of amyloidogenesis proteins such as amyloid-β precursor protein (APP), C99, and β-secretase-1 (BACE-1); production of inflammatory proteins such as Iba-1, GFAP, inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX)-2; activation of inflammatory pathways; and expression of inflammatory mediator mRNAs in hippocampal tissue. In cultured microglia, PTW treatment inhibited the generation of various inflammatory factors activated by LPS. CONCLUSION:
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Authors | Yun Hee Jeong, You-Chang Oh, Malk Eun Pak, Wei Li, Younghoon Go, Jung-Jin Lee |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 79
Pg. 153338
(Dec 2020)
ISSN: 1618-095X [Electronic] Germany |
PMID | 32992081
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier GmbH. All rights reserved. |
Chemical References |
- Inflammation Mediators
- Lipopolysaccharides
- Plant Extracts
- Tea
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Topics |
- Animals
- Avoidance Learning
(drug effects)
- Brain
(drug effects, pathology)
- Cells, Cultured
- Cognitive Dysfunction
(chemically induced, prevention & control)
- Disease Models, Animal
- Fermented Foods
(analysis)
- Gene Expression Regulation
(drug effects)
- Hippocampus
(drug effects, pathology)
- Inflammation
(complications, drug therapy, metabolism, pathology)
- Inflammation Mediators
(metabolism)
- Lipopolysaccharides
(toxicity)
- Memory Disorders
(chemically induced, drug therapy)
- Mice, Inbred ICR
- Microglia
(drug effects, pathology)
- Plant Extracts
(analysis, chemistry, pharmacology)
- Tea
(chemistry)
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