Abstract | BACKGROUND: Sexual dimorphism has been demonstrated after major trauma and hemorrhage shock with protective effects related to female sex or estrogen. Traumatic endotheliopathy is an important component of trauma-induced coagulopathy. Components of endothelial barrier dysfunction include degradation of the endothelial glycocalyx and endothelial cellular injury. Estrogen modulates endothelial function via its membrane and cellular receptors. The effects of estrogen on the vascular endothelial barrier after trauma and hemorrhage shock are, however, unknown. This topic was studied in an in vitro model under flow conditions. METHODS: RESULTS: Treatment with estrogen but not testosterone mitigated the adverse effect of shock on endothelial and glycocalyx barrier properties. Our biomimetic model suggests a beneficial effect of estrogen administration after trauma and hemorrhage shock on the glycocalyx and endothelial barriers. CONCLUSION:
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Authors | Lawrence N Diebel, Madison Wheaton, David M Liberati |
Journal | Surgery
(Surgery)
Vol. 169
Issue 3
Pg. 678-685
(03 2021)
ISSN: 1532-7361 [Electronic] United States |
PMID | 32988619
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Estrogens
- Protective Agents
- Proteinase Inhibitory Proteins, Secretory
- SPINT1 protein, human
- Vascular Endothelial Growth Factor A
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Topics |
- Biomarkers
- Cells, Cultured
- Endothelial Cells
(drug effects, metabolism)
- Estrogens
(metabolism, pharmacology)
- Female
- Fluorescent Antibody Technique
- Glycocalyx
(metabolism)
- Human Umbilical Vein Endothelial Cells
(drug effects, metabolism)
- Humans
- Male
- Microfluidics
(methods)
- Phenotype
- Protective Agents
(metabolism, pharmacology)
- Proteinase Inhibitory Proteins, Secretory
(metabolism)
- Sex Factors
- Shock
(etiology, metabolism)
- Vascular Endothelial Growth Factor A
(metabolism)
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