Abstract | BACKGROUND: OBJECTIVE: To explore the effect of LED therapy on myocardial I/R-induced injury and seek the underlying mechanism. METHODS: Thirty rats were randomly divided into three groups: Control group (without LED treatment or myocardial I/R, n = 6), I/R group (with myocardial I/R only, n = 12), and LED+I/R group (with myocardial I/R and LED therapy, n = 12). Electrocardiogram was recorded continuously during the procedure. In addition, brain tissue was extracted for BDNF, Iba1, and CD206 analyses, and heart tissue for myocardial injury (ischemic size and infarct size), IL-4 and IL-10 mRNA analysis. RESULTS: In comparison with the I/R group, the ischemia size and the infarct size were significantly attenuated by LED therapy in the LED+I/R group. Meanwhile, the microglia activation induced by I/R injury was prominently attenuated by LED treatment either. And it is apparent that there was also an increase in the beneficial neuroinflammation markers ( BDNF and CD206) in the paraventricular nucleus (PVN) in the LED+I/R group. Furthermore, the anti-inflammatory cytokines, IL-4 and IL-10, were greatly decreased by I/R while improved by LED treatment in myocardium. CONCLUSION:
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Authors | Songyun Wang, Qinyu Luo, Hui Chen, Jingyu Huang, Xuemeng Li, Lin Wu, Binxun Li, Zhen Wang, Dongdong Zhao, Hong Jiang |
Journal | Oxidative medicine and cellular longevity
(Oxid Med Cell Longev)
Vol. 2020
Pg. 9343160
( 2020)
ISSN: 1942-0994 [Electronic] United States |
PMID | 32963707
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Songyun Wang et al. |
Chemical References |
- Brain-Derived Neurotrophic Factor
- RNA, Messenger
- Interleukin-10
- Interleukin-4
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Topics |
- Animals
- Brain
(pathology)
- Brain-Derived Neurotrophic Factor
(metabolism)
- Gene Expression Regulation
- Inflammation
(genetics, pathology, therapy)
- Interleukin-10
(genetics, metabolism)
- Interleukin-4
(genetics, metabolism)
- Microglia
(pathology)
- Myocardial Reperfusion Injury
(genetics, pathology, therapy)
- Myocardium
(metabolism, pathology)
- Phototherapy
- RNA, Messenger
(genetics, metabolism)
- Rats, Sprague-Dawley
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