[Non-aspergillus molds infection after allogeneic stem cell transplantation: clinical analysis of 24 cases and outcomes].

Abstract

Objective: To analyze the clinical characteristics and outcomes of non-aspergillus molds infection (NAMI) patients who underwent allogeneic stem cell transplantation. Methods: Total 24 patients diagnosed as proven or probable non-aspergillus molds infection after allo-HSCT at the Peking University Institute of Hematology from January 2010 to December 2016 were retrospectively reviewed. Results: Among the 24 non-aspergillus molds infection patients, 22 (91.6%) underwent haploidentical stem cell transplantation, while 1 (4.2%) underwent matched-sibling donor transplantation, and 1 (4.2%) underwent HLA-matched unrelated donor transplantation. Ten (41.7%) patients were diagnosed as proven NAMI, and 14 (58.3%) were probable NAMI. The median time to NAMI diagnosis was 188 (2-856) d after transplantation. Five (20.8%) patients had Mucorales infection, 14 (58.3%) Rhizopus infection, 3 (12.5%) had Absidia orchidis infection, and 2 (8.3%) had Scedosporium apiospermum infection. The response rate at was 38.9% (7/18) in 18 patients who adjusted antifungal therapy based on the etiology. After a median 229 (2-2280) days follow-up after diagnosis, the 2-year overall survival was (24.0±14.5) %. Conclusion: The major pathogen of NAMI after allo-HSCT was Rhizopus, and the mortality of NAMI after allo-HSCT was very high due to lack of early effective therapy.

• Authors: C Zhao, Q Wang, Y Wang, C H Yan, L P Xu, X H Zhang, K Y Liu, X J Huang, Y Q Sun
• Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi (Zhonghua Xue Ye Xue Za Zhi) Vol. 41 Issue 8 Pg. 624-629 (Aug 14 2020) ISSN: 0253-2727 [Print] China
• PMID: 32942814 (Publication Type: Journal Article)

Topics

• Graft vs Host Disease
• Hematopoietic Stem Cell Transplantation (adverse effects)
• Humans
• Infections
• Mycoses (etiology)
• Retrospective Studies
• Siblings
• Transplantation, Homologous