Silver(I) Coordination Polymers: Photocatalytic Properties and Enhanced Treatment Activity of Haloperidol on Children Tic Disorder by Regulating Neurotransmitter Content.

Abstract

In this article, the characterization, synthesis, as well as the photocatalysis dye degradation performance of two novel silver(I) coordination polymers, namely, [Ag(L)(Hbdc)]n (1, L = 1,4-Bis(5,6-dimethylbenzimidazol-1-yl)butane, H2bdc = 1,4-Benzenedicarboxylic acid) and [Ag2(L)(hip)]n (2, H2hip = 5-Hydroxyisophthalic acid), were investigated. Fascinatingly, the photocatalytic performance of Complexes 1 and 2 have been investigated, wherein Complex 2 is considered an excellent photocatalyst for degrading Rhodamine B/methyl violet/methylene blue mixed organic dyes. Furthermore, the treatment activities of Complexes 1 and 2 on Tic disorder (TD) were assessed when used with haloperidol, and biochemical studies were conducted to reveal the mechanism in detail. Initially, the enzyme-linked immunosorbent assay was carried out to determine the dopamine and high vanillic acid contents in the striatum of the TD animal model. Subsequently, the reverse transcription-polymerase chain reaction was utilized to determine the relative expression of dopamine 1 and 2 receptor.

• Authors: Hui-Li Qian, Xin Yu, Guo-Feng Liu
• Journal: Journal of fluorescence (J Fluoresc) Vol. 30 Issue 6 Pg. 1411-1419 (Dec 2020) ISSN: 1573-4994 [Electronic] Netherlands
• PMID: 32930925 (Publication Type: Journal Article)

Chemical References

• Coordination Complexes
• Neurotransmitter Agents
• Polymers
• Receptors, Dopamine
• Silver
• Haloperidol

Topics

• Catalysis
• Child
• Coordination Complexes (chemistry)
• Drug Synergism
• Gene Expression Regulation (drug effects)
• Haloperidol (pharmacology, therapeutic use)
• Humans
• Neurotransmitter Agents (metabolism)
• Photochemical Processes
• Polymers (chemistry, pharmacology)
• Receptors, Dopamine (metabolism)
• Silver (chemistry)
• Tic Disorders (drug therapy, metabolism)