Abstract | BACKGROUND: METHODS: The study population consisted of a cohort of consecutive patients who underwent surgery for lung cancer at Nagasaki University Hospital, Nagasaki, Japan, from January 2009 to December 2010. Patient characteristics, survival and disease-free survival (DFS), and laboratory findings were compared between patients who tested positive and negative for HSP47 expression in lung cancer cells and between those who showed high and low numbers of HSP47-positive fibroblasts in cancer stroma. RESULTS: A total of 133 patients underwent surgery for lung cancer. Sixty-seven patients (50.4%) had HSP47-positive cancer cells, and 91 patients (68.4%) had a higher number of HSP47-positive fibroblasts. The patients with a high number of HSP47-positive fibroblasts had a shorter DFS than those with a low number of HSP47-positive fibroblasts. Multivariate analysis identified only the presence of a high number of HSP47-positive fibroblasts as an independent risk factor for recurrence of lung cancer after surgery (odds ratio, 4.371; 95% confidence interval, 1.054-29.83; P = 0.042). CONCLUSION: The present study demonstrated that the presence of a high number of HSP47-positive fibroblasts in the cancer stroma was a risk factor for recurrence of lung cancer after surgery.
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Authors | Takuto Miyamura, Noriho Sakamoto, Kaori Ishida, Tomoyuki Kakugawa, Hirokazu Taniguchi, Yoshiko Akiyama, Daisuke Okuno, Atsuko Hara, Takashi Kido, Hiroshi Ishimoto, Takuro Miyazaki, Keitaro Matsumoto, Tomoshi Tsuchiya, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Takeshi Nagayasu, Hiroshi Mukae |
Journal | Respiratory research
(Respir Res)
Vol. 21
Issue 1
Pg. 234
(Sep 14 2020)
ISSN: 1465-993X [Electronic] England |
PMID | 32928242
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- HSP47 Heat-Shock Proteins
- SERPINH1 protein, human
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Topics |
- Aged
- Biomarkers, Tumor
(biosynthesis, genetics)
- Carcinoma, Squamous Cell
(genetics, metabolism, surgery)
- Female
- Fibroblasts
(metabolism)
- HSP47 Heat-Shock Proteins
(biosynthesis, genetics)
- Humans
- Lung Neoplasms
(genetics, metabolism, surgery)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(genetics, metabolism)
- Retrospective Studies
- Risk Factors
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