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Heat-Shock Proteins (Heat-Shock Protein)

Proteins which are synthesized in eukaryotic organisms and bacteria in response to hyperthermia and other environmental stresses. They increase thermal tolerance and perform functions essential to cell survival under these conditions.
Also Known As:
Heat-Shock Protein; Heat Shock Protein; Heat Shock Proteins; Protein, Stress; Stress Protein; Stress Proteins
Networked: 8088 relevant articles (215 outcomes, 816 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Calderwood, Stuart K: 42 articles (01/2022 - 04/2002)
2. Neckers, Len: 34 articles (01/2019 - 01/2002)
3. Multhoff, Gabriele: 33 articles (01/2022 - 05/2004)
4. Workman, Paul: 29 articles (11/2018 - 01/2002)
5. Blagg, Brian S J: 28 articles (12/2021 - 09/2006)
6. Chiosis, Gabriela: 28 articles (07/2021 - 10/2002)
7. Garrido, Carmen: 21 articles (11/2022 - 11/2003)
8. van Eden, Willem: 21 articles (01/2020 - 03/2002)
9. Li, Zihai: 18 articles (07/2021 - 10/2002)
10. Gong, Jianlin: 17 articles (01/2018 - 07/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Infections
3. Hyperthermia
06/01/2001 - "We examined the effect of aging on the capacity of the brain to produce heat shock protein (Hsp70) in response to heat stress, using high-powered microwaves (HPM, 2.06 GHz, 2.2 W/cm(2)) to induce hyperthermia for periods so brief that thermoregulatory factors were functionally eliminated as confounding variables. "
02/01/1992 - "Although ventricular samples from rats subjected to either hyperthermia (n = 7) or ischemic pretreatment (n = 6) all showed induction of HSP72 (heat shock protein), Western blot analysis revealed significantly greater amounts of HSP72 in samples obtained from rats subjected to hyperthermia compared with those from rats subjected to ischemic pretreatment. "
05/01/2011 - "Chronic repeated exposure to hyperthermia in humans results in heat acclimation (HA), an adaptive process that is attained in humans by repeated exposure to hyperthermia and is characterized by improved heat elimination and increased exercise capacity, and acquired thermal tolerance (ATT), a cellular response characterized by increased baseline heat shock protein (HSP) expression and blunting of the acute increase in HSP expression stimulated by re-exposure to thermal stress. "
01/01/2011 - "Hyperthermia has been shown to induce expression of heat shock proteins (HSPs) to provide protection against a variety of stresses. "
03/01/1998 - "Improved cardiac post-ischemic recovery after whole-body hyperthermia is correlated with an increased expression of the heat shock proteins (hsps). "
4. Inflammation (Inflammations)
5. Reperfusion Injury

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Peptides (Polypeptides)
3. Vaccines
4. tanespimycin (17AAG)
5. Antigens
6. Antibodies
7. Heat-Shock Proteins (Heat-Shock Protein)
8. Epitopes
9. Heme Oxygenase-1
10. STA 9090

Related Therapies and Procedures

1. Therapeutics
2. Immunotherapy
3. Photothermal Therapy
4. Drug Therapy (Chemotherapy)
5. Lasers (Laser)