Abstract |
The COVID-19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process, is reported. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS-CoV-2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID-19.
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Authors | Meng Qin, Zheng Cao, Jing Wen, Qingsong Yu, Chaoyong Liu, Fang Wang, Jianjun Zhang, Fengmei Yang, Yanyan Li, Gregory Fishbein, Sen Yan, Bin Xu, Yi Hou, Zhenbo Ning, Kaili Nie, Ni Jiang, Zhen Liu, Jun Wu, Yanting Yu, Heng Li, Huiwen Zheng, Jing Li, Weihua Jin, Shen Pang, Shuai Wang, Jianfeng Chen, Zhihua Gan, Zhanlong He, Yunfeng Lu |
Journal | Advanced materials (Deerfield Beach, Fla.)
(Adv Mater)
Vol. 32
Issue 43
Pg. e2004901
(Oct 2020)
ISSN: 1521-4095 [Electronic] Germany |
PMID | 32924219
(Publication Type: Journal Article)
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Copyright | © 2020 Wiley-VCH GmbH. |
Chemical References |
- Anti-Inflammatory Agents
- Antioxidants
- Catalase
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacokinetics, therapeutic use)
- Antioxidants
(pharmacokinetics, therapeutic use)
- Betacoronavirus
(drug effects, physiology)
- COVID-19
- Catalase
(pharmacokinetics, therapeutic use)
- Cell Line
- Coronavirus Infections
(drug therapy, metabolism, virology)
- Humans
- Leukocytes
(drug effects, metabolism, virology)
- Macaca mulatta
- Mice
- Mice, Inbred BALB C
- Oxidative Stress
(drug effects)
- Pandemics
- Pneumonia, Viral
(drug therapy, metabolism, virology)
- Pulmonary Alveoli
(drug effects, metabolism, virology)
- SARS-CoV-2
- Virus Replication
(drug effects)
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