Abstract | BACKGROUND AND AIMS: METHODS AND RESULTS: A total of 3181 patients with AMI were included in the analysis. Patients were stratified into 2 groups according to their TyG index levels: the TyG index <8.88 group and the TyG index ≥8.88 group. The incidence of major adverse cardiovascular events (MACEs) during a median of 33.3-month follow-up were recorded. Multivariable Cox regression models revealed that the TyG index was positively associated with all-cause death [HR (95% CI): 1.51 (1.10,2.06), p = 0.010], cardiac death [HR (95% CI): 1.68 (1.19,2.38), p = 0.004], revascularization [HR (95% CI): 1.50 (1.16,1.94), p = 0.002], cardiac rehospitalization [HR (95% CI): 1.25 (1.05,1.49), p = 0.012], and composite MACEs [HR (95% CI): 1.19 (1.01,1.41), p = 0.046] in patients with AMI. The independent predictive effect of TyG index on composite MACEs was mainly reflected in the subgroups of male gender and smoker. The area under the curve (AUC) of the TyG index predicting the occurrence of MACEs in AMI patients was 0.602 [95% CI 0.580,0.623; p < 0.001]. CONCLUSION: High TyG index levels appeared to be associated with an increased risk of MACEs in patients with AMI. The TyG index might be a valid predictor of cardiovascular outcomes of patients with AMI. TRIAL REGISTRATION: Retrospectively registered.
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Authors | Yue Zhang, Xiaosong Ding, Bing Hua, Qingbo Liu, Hui Gao, Hui Chen, Xue-Qiao Zhao, Weiping Li, Hongwei Li |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 30
Issue 12
Pg. 2351-2362
(11 27 2020)
ISSN: 1590-3729 [Electronic] Netherlands |
PMID | 32917496
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020. Published by Elsevier B.V. |
Chemical References |
- Biomarkers
- Blood Glucose
- Triglycerides
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Topics |
- Aged
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Databases, Factual
- Female
- Heart Disease Risk Factors
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Non-ST Elevated Myocardial Infarction
(blood, diagnosis, mortality, physiopathology)
- Predictive Value of Tests
- Prognosis
- Retrospective Studies
- Risk Assessment
- ST Elevation Myocardial Infarction
(blood, diagnosis, mortality, physiopathology)
- Triglycerides
(blood)
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