Abstract | BACKGROUND: Patients infected with SARS-CoV-2 often develop venous and arterial thrombosis. The high patient mortality is partly attributed to thrombotic events. An emerging trend is the presence of immunological phenomena including antiphospholipid antibodies which may promote thrombosis. The mechanism for these observations is not clear though many patients with SARS-CoV-2 develop thrombocytopenia. CASE PRESENTATION: CONCLUSIONS: Since excessive platelet activation and in situ thrombosis occur in HIT, this case underscores the need to consider that thrombocytopenia in patients with SARS-CoV-2-most of whom receive heparinoids-may be unrecognized HIT. A central role for the platelet in the etiology of thrombosis during the COVID-19 pandemic should be explored.
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Authors | Michael Tran, Chirag Sheth, Rohan Bhandari, Scott J Cameron, Deborah Hornacek |
Journal | Thrombosis journal
(Thromb J)
Vol. 18
Pg. 16
( 2020)
ISSN: 1477-9560 [Print] England |
PMID | 32905282
(Publication Type: Case Reports)
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Copyright | © The Author(s) 2020. |