Abstract | BACKGROUND: METHODS: We measured the olfactory threshold score in a total of 518 children (10-12 years old, 264 boys) using the Sniffin' Sticks kit, and the children were divided into tertiles according to olfactory threshold score. We also assessed serum 25[ OH]D level, common aeroallergen-specific immunoglobulin E, rhinitis severity with visual analog scale, and the Total Four Symptom Score, and pre- and post- decongestant nasal patency with acoustic rhinometry. RESULTS: The children with 25( OH)D deficiency had significantly reduced mean olfactory threshold scores when compared to those with 25( OH)D levels of ≥20.0 ng/mL (6.56 ± 3.54 and 7.28 ± 3.87, respectively, P = .036). The proportion of loss of smell function and pre- decongestant nasal patency significantly associated with low 25( OH)D levels (chi-square trend test, P for trend = .007). Likewise, after adjustment for confounders, children with smell loss (third tertile) were significantly associated with low 25( OH)D level (aβ=-0.062, 95% CI=-0.064 to -0.060, P = .009) independent of aeroallergen sensitization, and a low pre- decongestant nasal patency. CONCLUSIONS:
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Authors | Youn Ho Shin, Eun Kyo Ha, Ju Hee Kim, Dong Keon Yon, Seung Won Lee, Hyeon Jeong Sim, Myongsoon Sung, Hye Mi Jee, Man Yong Han |
Journal | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
(Pediatr Allergy Immunol)
Vol. 32
Issue 1
Pg. 116-123
(01 2021)
ISSN: 1399-3038 [Electronic] England |
PMID | 32841423
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Child
- Humans
- Male
- Nasal Obstruction
- Olfaction Disorders
(etiology)
- Quality of Life
- Rhinitis, Allergic
- Vitamin D
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