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The in vivo roles of galectin-2 from Nile tilapia (Oreochromis niloticus) in immune response against bacterial infection.

Abstract
Our previous study has recorded that the recombinant protein of Nile tilapia (Oreochromis niloticus) galectin-2 (rOnGal-2) can enhance immune response against Streptococcus agalactiae (S.agalactiae) infection in vitro. In this study, we further explored the effects of OnGal-2 in immune response against bacterial infection in vivo. The administration of rOnGal-2 could improve serum antibacterial activity (ALKP, ACP, and LZM) and antioxidant capacity (CAT, POD, and SOD). After S. agalactiae infection, rOnGal-2 injection could reduce bacterial burden and decrease tissue damage in head kidney, spleen, and liver of tilapia. Also, rOnGal-2 regulated the inflammatory-related genes expression including IL-6, IL-8 and IL-10 during bacterial infection. Furthermore, rOnGal-2 administration could increase the relative percentage survival of tilapia infected with S.agalactiae. Taken together, our results indicate that OnGal-2 can protect fish from bacterial infection through reducing bacterial burden, impairing tissue damage and modulating anti-bacterial immune response, which also can be applied as a potential vaccine adjuvant in O.niloticus culture.
AuthorsJinzhong Niu, Xinchao Liu, Zhiqiang Zhang, Yu Huang, Jufen Tang, Bei Wang, Yishan Lu, Jia Cai, Jichang Jian
JournalFish & shellfish immunology (Fish Shellfish Immunol) Vol. 106 Pg. 473-479 (Nov 2020) ISSN: 1095-9947 [Electronic] England
PMID32805415 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Elsevier Ltd. All rights reserved.
Chemical References
  • Fish Proteins
  • Galectin 2
Topics
  • Animals
  • Cichlids (genetics, immunology)
  • Fish Diseases (immunology)
  • Fish Proteins (genetics, immunology)
  • Galectin 2 (genetics, immunology)
  • Gene Expression Profiling (veterinary)
  • Gene Expression Regulation (immunology)
  • Immunity, Innate (genetics)
  • Male
  • Streptococcal Infections (immunology, veterinary)
  • Streptococcus agalactiae (physiology)

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