Role of peroxisome proliferator-activated receptors in stroke prevention and therapy-The best is yet to come?

Abstract

Role of peroxisome proliferator-activated receptors (PPARs) in the pathophysiology of stroke and protective effects of PPAR ligands have been widely investigated in the last 20 years. Activation of all three PPAR isoforms, but especially PPAR-γ, was documented to limit postischemic injury in the numerous in vivo, as well as in in vitro studies. PPARs have been demonstrated to act on multiple mechanisms and were shown to activate multiple protective pathways related to inflammation, apoptosis, BBB protection, neurogenesis, and oxidative stress. The aim of this review was to summarize two decades of PPAR research in stroke with emphasis on in vivo animal studies. We focus on each PPAR receptor separately and detail their implication in stroke. This review also discusses recent clinical efforts in the field and the epidemiological data with regard to role of PPAR polymorphisms in susceptibility to stroke, and tries to draw conclusions and describe future perspectives.

• Authors: Marcin Gamdzyk, Cameron Lenahan, Jiping Tang, John H Zhang
• Journal: Journal of neuroscience research (J Neurosci Res) Vol. 98 Issue 11 Pg. 2275-2289 (11 2020) ISSN: 1097-4547 [Electronic] United States
• PMID: 32772463 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• Peroxisome Proliferator-Activated Receptors

Topics

• Animals
• Humans
• Ischemic Stroke (drug therapy, physiopathology, prevention & control)
• Peroxisome Proliferator-Activated Receptors (drug effects, genetics)
• Stroke (drug therapy, physiopathology, prevention & control)