The effects of selective beta-adrenergic blockade on bone marrow dysfunction following severe trauma and chronic stress.

Abstract

INTRODUCTION:

Propranolol has been shown to improve erythroid progenitor cell growth and anemia following trauma and this study sought to investigate the mechanisms involved by evaluating the effects of selective beta blockade.

METHODS:

Male Sprague-Dawley rats were subjected to lung contusion, hemorrhagic shock and chronic stress (LCHS/CS) ± daily selective beta-1, beta-2, or beta-3 blockade (B1B, B2B, B3B). Bone marrow cellularity and growth of erythroid progenitor colonies, hemoglobin, plasma granulocyte colony-stimulating factor (G-CSF), hematopoietic progenitor cell mobilization, and daily weight were assessed.

RESULTS:

Selective beta-2 and beta-3 blockade improved bone marrow cellularity, erythroid progenitor colony growth and hemoglobin levels, while decreasing plasma G-CSF, progenitor cell mobilization and weight loss following LCHS/CS.

CONCLUSIONS:

Attenuating the neuroendocrine stress response with the use of selective beta-2 and 3 adrenergic blockade may be an alternative to improve bone marrow erythroid function following trauma.

• Authors: Elizabeth S Miller, Camille G Apple, Kolenkode B Kannan, Zackary M Funk, Philip A Efron, Alicia M Mohr
• Journal: American journal of surgery (Am J Surg) Vol. 220 Issue 5 Pg. 1312-1318 (11 2020) ISSN: 1879-1883 [Electronic] United States
• PMID: 32741547 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Adrenergic beta-Antagonists
• Biomarkers
• Propranolol

Topics

• Adrenergic beta-Antagonists (pharmacology, therapeutic use)
• Animals
• Biomarkers (metabolism)
• Bone Marrow (drug effects, metabolism, pathology, physiopathology)
• Contusions (drug therapy, physiopathology)
• Lung Injury (drug therapy, physiopathology)
• Male
• Propranolol (pharmacology, therapeutic use)
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Shock, Hemorrhagic (drug therapy, physiopathology)
• Stress, Physiological (drug effects)