Prognostic and Predictive Value of Cadherin 11 for Patients with Gastric Cancer and Its Correlation with Tumor Microenvironment: Results from Microarray Analysis.

Abstract

Gastric cancer is a disease characterized by inflammation, and epithelial-to-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) both play a vital role in epithelial-driven malignancy. In the present study, we performed an integrated bioinformatics analysis of transcriptome data from multiple databases of gastric cancer patients and worked on a biomarker for evaluating tumor prognosis. We found that cadherin 11 (CDH11) is highly expressed not only in gastric cancer tissues but also in EMT molecular subtypes and metastatic patients. Also, we obtained evidence that CDH11 has a significant correlation with infiltrating immune cells in the tumor microenvironment (TME). Our findings reflected that CDH11 likely plays an important role in tumor immune escape and could provide a prognostic biomarker and potential therapeutic target for patients with gastric cancer.

• Authors: Zhijun Feng, Xue Li, Zhijian Ren, Jie Feng, Xiaodong He, Chongge You
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 8107478 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 32685527 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Zhijun Feng et al.

Chemical References

• Cadherins
• Neoplasm Proteins
• osteoblast cadherin

Topics

• Cadherins (biosynthesis, genetics)
• Epithelial-Mesenchymal Transition
• Female
• Gene Expression Profiling
• Humans
• Male
• Neoplasm Proteins (biosynthesis, genetics)
• Oligonucleotide Array Sequence Analysis
• Prognosis
• Stomach Neoplasms (diagnosis, genetics, metabolism)
• Tumor Microenvironment