Abstract |
Development of multifacted phototheranostics with bright fluorescence and absorbance in the second near infrared (NIR-II) window is very appealing for precise cancer diagnosis and treatment, but still challenging nowadays. Herein, we synthesize a hydrophobic annularly fused azaBODIPY (termed as HBP) molecule with sharp NIR absorbance peaked at 878 nm and bright NIR-II fluorescence. With Pluronic F127 as the surfactant and hydrophobic paclitaxel (PTX) as the spacer, such HBP molecule would self-assemble to form surfactant-stripped HBP/PTX micelles with absorption peak red-shifted to 1012 nm and intrinsic NIR-II fluorescence negligibly disturbed. We found that such HBP/PTX micelles can be utilized as a bimodal NIR-II nano-probe to enable real-time tracking of lymph nodes and tumors under an NIR-II fluorescence imaging system, as well as clear visualization of tumor microvasculatures under an NIR-II photoacoustic imaging system. Furthermore, together with 1064 nm laser exposure, such HBP/PTX micelles would synergistically suppress the growth of tumors grown on the mice upon tumor accumulation. This work highlights the concise preparation of a type of all-in-one NIR-II phototheranostics from the newly synthesized HBP molecules, thereby enables NIR-II fluorescence/photoacoustic bimodal imaging guided synergistic cancer treatment via the NIR-II laser boosted photothermal therapy and chemotherapy.
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Authors | Yicheng Zhang, Huiquan Tao, Quguang Li, Wanle Sheng, Yuejuan Xu, Erhong Hao, Meiwan Chen, Zhuang Liu, Liangzhu Feng |
Journal | Journal of controlled release : official journal of the Controlled Release Society
(J Control Release)
Vol. 326
Pg. 256-264
(10 10 2020)
ISSN: 1873-4995 [Electronic] Netherlands |
PMID | 32682904
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 Elsevier B.V. All rights reserved. |
Chemical References |
- Micelles
- Surface-Active Agents
- Paclitaxel
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Topics |
- Animals
- Mice
- Micelles
- Paclitaxel
- Photoacoustic Techniques
- Phototherapy
- Surface-Active Agents
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