Phosphorylation of 5-LOX: The Potential Set-point of Inflammation.
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| Abstract |
Inflammation secondary to tissue injuries serves as a double-edged sword that determines the prognosis of tissue repair. As one of the most important enzymes controlling the inflammation process by producing leukotrienes, 5-lipoxygenase (5-LOX, also called 5-LO) has been one of the therapeutic targets in regulating inflammation for a long time. Although a large number of 5-LOX inhibitors have been explored, only a few of them can be applied clinically. Surprisingly, phosphorylation of 5-LOX reveals great significance in regulating the subcellular localization of 5-LOX, which has proven to be an important mechanism underlying the enzymatic activities of 5-LOX. There are at least three phosphorylation sites in 5-LOX jointly to determine the final inflammatory outcomes, and adjustment of phosphorylation of 5-LOX at different phosphorylation sites brings hope to provide an unrecognized means to regulate inflammation. The present review intends to shed more lights into the set-point-like mechanisms of phosphorylation of 5-LOX and its possible clinical application by summarizing the biological properties of 5-LOX, the relationship of 5-LOX with neurodegenerative diseases and brain injuries, the phosphorylation of 5-LOX at different sites, the regulatory effects and mechanisms of phosphorylated 5-LOX upon inflammation, as well as the potential anti-inflammatory application through balancing the phosphorylation-depended set-point.
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| Authors | Zonglin He, Di Tao, Jiaming Xiong, Fangfang Lou, Jiayuan Zhang, Jinxia Chen, Weixi Dai, Jing Sun, Yuechun Wang |
| Journal | Neurochemical research (Neurochem Res) Vol. 45 Issue 10 Pg. 2245-2257 (Oct 2020) ISSN: 1573-6903 [Electronic] United States |
| PMID | 32671628 (Publication Type: Journal Article, Review) |
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