Head-to-Head Comparison of the Two MAO-B Radioligands, 18F-THK5351 and 11C-L-Deprenyl, to Visualize Astrogliosis in Patients With Neurological Disorders.

Abstract

Three patients with neurological disorders (cerebral infarction, progressive multifocal leukoencephalopathy, and multiple sclerosis) underwent F-THK5351 and C-L-deprenyl PET on the same day to visualize lesions undergoing astrogliosis by measuring MAO-B activity. BPND map and SUV image with F-THK5351 as well as Ki map, Ki/K1 map and SUV image with C-L-deprenyl were created. F-THK5351 BPND maps and SUV images clearly identified the lesions undergoing astrogliosis. C-L-deprenyl Ki/K1 maps were close to F-THK5351 images, but very noisy. Ki maps and SUV images were likely affected by the effect of blood flow. Hence, F-THK5351 is superior to C-L-deprenyl for visualizing lesions undergoing astrogliosis.

• Authors: Kenji Ishibashi, Masashi Kameyama, Yoshiharu Miura, Jun Toyohara, Kenji Ishii
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 46 Issue 1 Pg. e31-e33 (Jan 2021) ISSN: 1536-0229 [Electronic] United States
• PMID: 32657879 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Aminopyridines
• Carbon Radioisotopes
• Carbon-11
• Ligands
• Quinolines
• THK5351
• Selegiline
• Monoamine Oxidase

Topics

• Aminopyridines (metabolism)
• Carbon Radioisotopes
• Female
• Gliosis (complications, diagnostic imaging, metabolism)
• Humans
• Ligands
• Male
• Monoamine Oxidase (metabolism)
• Nervous System Diseases (complications)
• Positron-Emission Tomography
• Quinolines (metabolism)
• Selegiline (metabolism)