Abstract | BACKGROUND: METHODS: Electronic databases were searched from their inception to February 2019. Inclusion criteria included reports of anaplastic ependymoma with extraneural metastasis. Studies were excluded if the tumor grade was not reported. A case illustration is provided. RESULTS: The search yielded 15 cases of anaplastic ependymoma with extraneural metastases, including the present case. Mean age at diagnosis was 15 years. The initial tumor location was predominantly supratentorial (93.3%). All cases demonstrated leptomeningeal seeding before extraneural metastasis. Mean survival from initial diagnosis was 4.5 years. Metastasis to the parotid gland occurred in 2 cases, including the present case. We present a 17-year-old female patient who underwent gross total resection of a supratentorial, paraventricular anaplastic ependymoma followed by adjuvant external beam radiation therapy. The patient developed recurrent leptomeningeal seeding, treated with Gamma Knife radiosurgery over a 5-year period. She returned with a parotid mass and cervical lymphadenopathy and underwent parotidectomy and modified radical neck dissection. She continued to experience recurrences, including the left parotid gland, and was ultimately placed in hospice care. CONCLUSIONS:
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Authors | Gray Umbach, Tarek Y El Ahmadieh, Aaron R Plitt, Salah G Aoun, Om J Neeley, Kristopher A Lyon, Ekokobe Fonkem, Jack M Raisanen, Justin A Bishop, Zabi Wardak, Toral R Patel, Larry Myers, Bruce E Mickey |
Journal | Neuro-oncology practice
(Neurooncol Pract)
Vol. 7
Issue 2
Pg. 218-227
(Mar 2020)
ISSN: 2054-2577 [Print] England |
PMID | 32626590
(Publication Type: Journal Article)
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Copyright | © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. All rights reserved. For permissions, please e-mail: [email protected]. |