Abstract | CONTEXT: OBJECTIVE: DESIGN: Multicenter cross-sectional study. SETTING: Twelve European referral centers. PATIENTS: INTERVENTION: In patients with PPGLs, surgical resection of tumors. OUTCOME MEASURES: Differences in mass spectrometry-based profiles of 15 adrenal steroids between groups and after surgical resection of PPGLs. Relationships of steroids to plasma and urinary metanephrines and urinary catecholamines. RESULTS: Patients with pheochromocytoma had higher (P < .05) circulating concentrations of cortisol, 11-deoxycortisol, 11-deoxycorticosterone, and corticosterone than patients with primary hypertension. Concentrations of cortisol, 11-deoxycortisol, and corticosterone were also higher (P < .05) in patients with pheochromocytoma than with paraganglioma. These steroids correlated positively with plasma and urinary metanephrines and catecholamines in patients with pheochromocytoma, but not paraganglioma. After adrenalectomy, there were significant decreases in cortisol, 11-deoxycortisol, corticosterone, 11-deoxycorticosterone, aldosterone, and 18-oxocortisol. CONCLUSIONS: This is the first large study in patients with PPGLs that supports in a clinical setting the concept of adrenal cortical-medullary interactions involving an influence of catecholamines on adrenal steroids. These findings could have implications for the cardiovascular complications of PPGLs and the clinical management of patients with the tumors.
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Authors | Georgiana Constantinescu, Katharina Langton, Catleen Conrad, Laurence Amar, Guillaume Assié, Anne-Paule Gimenez-Roqueplo, Anne Blanchard, Casper K Larsen, Paolo Mulatero, Tracy Ann Williams, Aleksander Prejbisz, Martin Fassnacht, Stefan Bornstein, Filippo Ceccato, Stephanie Fliedner, Michael Dennedy, Mirko Peitzsch, Richard Sinnott, Andrzej Januszewicz, Felix Beuschlein, Martin Reincke, Maria-Christina Zennaro, Graeme Eisenhofer, Jaap Deinum |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 105
Issue 9
(09 01 2020)
ISSN: 1945-7197 [Electronic] United States |
PMID | 32609829
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © Endocrine Society 2020. |
Chemical References |
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Topics |
- Adrenal Gland Neoplasms
(blood, complications, physiopathology, surgery)
- Adult
- Aged
- Cross-Sectional Studies
- Europe
(epidemiology)
- Female
- Glucocorticoids
(blood)
- Humans
- Hyperaldosteronism
(etiology, metabolism, physiopathology, surgery)
- Hypertension
(blood, etiology, physiopathology, surgery)
- Male
- Middle Aged
- Paraganglioma
(blood, complications, physiopathology, surgery)
- Pheochromocytoma
(blood, complications, physiopathology, surgery)
- Retrospective Studies
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