Epigenetic Changes Associated With Interleukin-10.

Abstract

IL-10 is a regulator of inflammation and immunosuppression. IL-10 regulates a variety of immune cells to limit and stop the inflammatory response, and thus plays an important role in autoimmune diseases, inflammatory diseases and cancer. IL-10 is closely related to epigenetic modification, in which changes in DNA methylation of IL-10 gene can affect mRNA and protein levels of IL-10. In addition, changes in histone modifications, especially histone acetylation, can also lead to abnormal expression of IL-10 mRNA. At the same time, a handful of IL-10 related microRNAs (miRNAs) are found to be aberrantly expressed in multiple diseases. Besides, long non-coding RNA (lncRNA) growth arrest specific transcript 5 (GAS5) also inhibits IL-10 expression. Here, we reviewed the epigenetic changes related to IL-10 in various diseases, as well as the regulation of IL-10 gene expression in various diseases by epigenetic modifications such as DNA methylation, histone modification, miRNA, and lncRNA.

• Authors: Zhonghua Zheng, Gang Huang, Tong Gao, Tianyi Huang, Mengsha Zou, Yuhao Zou, Shiwei Duan
• Journal: Frontiers in immunology (Front Immunol) Vol. 11 Pg. 1105 ( 2020) ISSN: 1664-3224 [Electronic] Switzerland
• PMID: 32582189 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Zheng, Huang, Gao, Huang, Zou, Zou and Duan.

Chemical References

• IL10 protein, human
• MicroRNAs
• RNA, Long Noncoding
• Interleukin-10

Topics

• Animals
• Autoimmune Diseases (genetics, immunology)
• DNA Methylation
• Epigenesis, Genetic
• Female
• Histone Code
• Humans
• Immune Tolerance (genetics, immunology)
• Inflammation (genetics, immunology)
• Interleukin-10 (genetics, metabolism)
• Male
• MicroRNAs (genetics)
• RNA, Long Noncoding (genetics)