PCSK9 and HS-CRP Predict Progression of Aortic Stenosis in Patients with Stable Coronary Artery Disease.

Abstract

It is essential to study the factors associated with the evolution of aortic stenosis progression (ASP) to develop therapies that could reduce it. We studied 283 patients 6 months after acute coronary syndrome (ACS). ASP was defined as an increase in the maximum aortic velocity of at least 0.5 m/s between the echocardiogram performed during ACS hospitalization and the last one recorded in the electronic medical registry. The median follow-up was 72.4 months. Twenty patients (7%) had ASP. A multivariate binary logistic regression analysis was performed showing that PCSK9 plasma levels (OR, 0.668 CI (0.457-0.977); p = 0.038), HS-CRP (OR, 1.034 CI (1.005-1.063); p = 0.022), the presence of dyslipidemia (OR, 4.622 CI (1.285-16.618); p = 0.019), the history of PAD (OR, 9.453 CI (1.703-52.452); p = 0.010), and GFR (OR, 0.962 CI (0.939-0.986); p = 0.002) were independent predicting factors of ASP. In patients with ischemic heart disease, low plasma levels of PCSK9 and elevated levels of HS-CRP are independent predictors of ASP.

• Authors: Álvaro Aceña, Juan Antonio Franco Peláez, Ana María Pello Lázaro, Emilio Gonzalez Parra, Óscar Gonzalez Lorenzo, Juan Martínez-Milla, Ignacio Hernandez, María Luisa Martín-Mariscal, Marta Lopez Castillo, Andrea Kallmeyer, Oscar Lorenzo, María Luisa González-Casaus, Jesús Egido, José Tuñón
• Journal: Journal of cardiovascular translational research (J Cardiovasc Transl Res) Vol. 14 Issue 2 Pg. 238-245 (04 2021) ISSN: 1937-5395 [Electronic] United States
• PMID: 32577988 (Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• C-Reactive Protein
• PCSK9 protein, human
• Proprotein Convertase 9

Topics

• Aged
• Aortic Valve Stenosis (blood, diagnostic imaging)
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Coronary Artery Disease (blood, diagnosis)
• Disease Progression
• Echocardiography
• Female
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Proprotein Convertase 9 (blood)
• Risk Assessment
• Risk Factors