Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats.

Abstract

Qingda granules (QDG) are derived from QingXuanJiangYa Decoction (QXJYD) a traditional Chinese medication that has been used to treat hypertension for more than 60 years. QXJYD has been shown to be effective in rat models of hypertension. However, the effects of QDG on hypertension remain largely unknown. In the current study, baicalin was identified as one of the main components of QDG using Ultra Performance Liquid Chromatography (UPLC) analysis. We investigated the effects of QDG on blood pressure, cardiac remodeling, and cardiac inflammation. QDG (0.8 g/kg/day) treatment attenuated the elevated blood pressure in spontaneously hypertensive rats (SHRs). Moreover, QDG treatment reduced the degree of myocardial fiber disarray, degeneration and necrosis of myocardial cells, expression of ANP and BNP, as well as collagen content of SHRs. Moreover, we further assessed the effect of QDG treatment on cardiac inflammation and found that QDG treatment reduced CD68 protein expression, decreased levels of IL-6 and TNF-α in both serum and cardiac tissues, as well as suppressed activation of NF-κB pathway in cardiac tissues of SHRs. Differential expressed metabolites (DEMs) analysis identified 41 increased and 51 decreased metabolites in the cardiac tissues of SHRs after QDG treatment. In summary, QDG treatment of SHRs attenuated the elevated blood pressure and ameliorated cardiac remodeling and inflammation, in part, through suppression of NF-κB pathway and DEMs, which provide a basis for other therapeutic uses of this TCM.

• Authors: Xiangyan Wu, Aling Shen, Liya Bao, Meizhu Wu, Xiaoying Lin, Huai Wang, Youqin Chen, Qiaoyan Cai, Shan Lin, Xueling Zhou, Yan Lu, Meizhong Peng, Daxin Chen, Jianfeng Chu, Jun Peng
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 129 Pg. 110367 (Sep 2020) ISSN: 1950-6007 [Electronic] France
• PMID: 32559624 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• Antihypertensive Agents
• CD68 protein, rat
• Drugs, Chinese Herbal
• Il6 protein, rat
• Interleukin-6
• NF-kappa B
• Tumor Necrosis Factor-alpha
• qingda granules

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Antigens, CD (metabolism)
• Antigens, Differentiation, Myelomonocytic (metabolism)
• Antihypertensive Agents (pharmacology)
• Blood Pressure (drug effects)
• Cardiomegaly (metabolism, pathology, physiopathology, prevention & control)
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology)
• Fibrosis
• Hypertension (drug therapy, metabolism, pathology, physiopathology)
• Inflammation (metabolism, pathology, physiopathology, prevention & control)
• Interleukin-6 (metabolism)
• Macrophages (drug effects, metabolism)
• Male
• Myocytes, Cardiac (drug effects, metabolism, pathology)
• NF-kappa B (metabolism)
• Necrosis
• Rats, Inbred SHR
• Rats, Inbred WKY
• Signal Transduction
• Tumor Necrosis Factor-alpha (metabolism)
• Ventricular Remodeling (drug effects)