Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis.
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| Abstract |
Invasive pulmonary aspergillosis is a major life-threatening complication among transplant recipients and patients receiving cancer chemotherapy. In a rat model of progressive pulmonary aspergillosis that is characterized by hyphal bronchopneumonia, aerosol amphotericin B (aero-AmB; 1.6 mg/kg given 2 days before infection) significantly delayed mortality in rats compared with animals in a control group. The first death in the aero-AmB-treated group occurred on day 11, by which time seven of the eight control animals had died. The same dose of aero-AmB given as treatment (1.6 mg/kg given 24 h after infection and then daily for 6 days) was also effective. In this trial, eight of the ten animals treated with aero-AmB survived for 7 days, whereas only one of ten control animals survived. Colony counts in lung homogenates obtained 24 h after infection showed an 80-fold reduction in the number of viable spores in animals that had received 6.4-mg/kg doses of aero-AmB 2 days prior to infection. At 48 h after administering a single 1.6- or 3.2-mg/kg dose of aero-AmB, mean lung concentrations were 2.79 and 5.22 micrograms/g of tissue, respectively. We conclude, therefore, that aero-AmB kills inhaled spores and delays the progression of pulmonary aspergillosis by inhibiting mycelial proliferation.
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| Authors | H J Schmitt, E M Bernard, M Häuser, D Armstrong |
| Journal | Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 32 Issue 11 Pg. 1676-9 (Nov 1988) ISSN: 0066-4804 [Print] United States |
| PMID | 3252750 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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