Abstract |
We have investigated the effect of subchronic exposure to tetradifon (TDF), as an endocrine disruptor chemical, on some parameters related to serious metabolomic disorders such as obesity, type 2 diabetes and hyperlipidemia. TDF promoted significant increases in both duodenal and pancreatic α- amylase and lipase especially in the 12-weeks treated rats. Plasmatic glucose and lipid profile; total cholesterol (T- cholesterol), low density lipoprotein-cholesterol ( LDL-c), high-density lipoprotein-cholesterol (HDL-c) and glyceride, were markedly disrupted. Compared with controls, biochemical liver injury parameters: aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and lactate dehydrogenase (LDH) were significantly increased. Moreover, notable pathological features were reported in liver tissues. These results confirm a strong relationship between exposure to an endocrine disruptor and metabolic disorders. In fact, subchronic exposure to TDF lead to lipidemic and glycemic disruption associated hyperactivity in both α- amylase and lipase. Overall, these disruptions could be an important step on the pathway to metabolic pathology.
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Authors | Riadh Badraoui, Hmed Ben-Nasr, Fevzi Bardakçi, Tarek Rebai |
Journal | Pesticide biochemistry and physiology
(Pestic Biochem Physiol)
Vol. 167
Pg. 104606
(Jul 2020)
ISSN: 1095-9939 [Electronic] United States |
PMID | 32527427
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Chemical References |
- Endocrine Disruptors
- Hydrocarbons, Chlorinated
- Lipase
- alpha-Amylases
- tetradifon
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Topics |
- Animals
- Diabetes Mellitus, Type 2
- Endocrine Disruptors
- Hydrocarbons, Chlorinated
- Lipase
- Liver
- Rats
- alpha-Amylases
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