Abstract |
The protective effects of caffeic acid on angiotensin-converting enzyme (ACE) and purinergic enzyme activities, as well as gluconeogenesis was investigated in iron-induced cardiotoxicity. Cardiotoxicity was induced in heart tissues harvested from healthy male SD rats by 0.1 mM FeSO4. Treatment was carried out by co-incubating hearts tissues with caffeic acid and 0.1 mM FeSO4. Cardiotoxicity induction significantly (p < 0.05) depleted GSH level, SOD, catalase, and ENTPDase activities, with concomitant elevation of the levels of malondialdehyde (MDA), nitric oxide, ACE, ATPase, glycogen phosphorylase, glucose 6-phosphatase, fructose 6-biphsophatase, and lipase activities. There was significant (p < 0.05) reversion in these levels and activities on treatment with caffeic acid. Caffeic acid also caused depletion in cardiac levels of cholesterol, triglyceride, LDL-c, while elevating HDL-c level. Our results suggest the protective effect of caffeic acid against iron-mediated cardiotoxicity as indicated by its ability to suppress oxidative imbalance and ACE activity, while concomitantly modulating nucleotide hydrolysis and metabolic switch.
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Authors | Veronica F Salau, Ochuko L Erukainure, Md Shahidul Islam |
Journal | Biological trace element research
(Biol Trace Elem Res)
Vol. 199
Issue 3
Pg. 1052-1061
(Mar 2021)
ISSN: 1559-0720 [Electronic] United States |
PMID | 32506180
(Publication Type: Journal Article)
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Chemical References |
- Angiotensins
- Antioxidants
- Caffeic Acids
- Lipids
- Nucleotides
- Iron
- caffeic acid
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Topics |
- Angiotensins
- Animals
- Antioxidants
- Caffeic Acids
(pharmacology)
- Cardiotoxicity
(prevention & control)
- Gluconeogenesis
- Iron
- Lipids
- Male
- Nucleotides
- Oxidative Stress
- Rats
- Rats, Sprague-Dawley
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