IL17F rs763780 single nucleotide polymorphism is associated with asthma after bronchiolitis in infancy.

Abstract

AIM:

Interleukin-17F (IL-17F) is involved with asthma. The aim of this study was to evaluate the association of IL17F polymorphisms with childhood asthma after bronchiolitis in infancy.

METHODS:

We invited 166 children who were hospitalised for bronchiolitis at younger than 6 months of age to follow-up visits at 5-7 years and 11-13 years of ages. Asthma and allergy diagnoses, asthma-presumptive symptoms and use of inhaled corticosteroids (ICSs) were registered. Blood samples were available for IL17F rs763780 (T/C), rs11465553 (C/T) and rs7741835 (C/T) determinations in 165 cases.

RESULTS:

The presence of IL17F rs11465553 and rs7741835 variations showed no significant associations with any asthma or allergy outcome at either 5-7 years or 11-13 years of ages. Instead, children with the variant IL17F rs763780 genotype had used more often ICSs between the follow-up visits from 5-7 to 11-13 years (adjusted OR 3.58) than those with the wild genotype. Children with the variant IL17F rs763780 genotype reported more often doctor-diagnosed atopic dermatitis (adjusted OR 2.71) at 11-13 years of age than those with the wild genotype.

CONCLUSION:

This prospective long-term follow-up study provided preliminary evidence on the association of the IL17F rs763780 polymorphism with asthma at school age after bronchiolitis in infancy.

• Authors: Annukka Holster, Johanna Teräsjärvi, Alex-Mikael Barkoff, Eero Lauhkonen, Sari Törmänen, Merja Helminen, Matti Korppi, Qiushui He, Kirsi Nuolivirta
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 110 Issue 1 Pg. 222-227 (01 2021) ISSN: 1651-2227 [Electronic] Norway
• PMID: 32495451 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Chemical References

• IL17F protein, human
• Interleukin-17

Topics

• Asthma (genetics)
• Bronchiolitis (genetics)
• Child
• Follow-Up Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Infant
• Interleukin-17 (genetics)
• Polymorphism, Single Nucleotide
• Prospective Studies