A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo.

Abstract

Dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders characterized by ventricular dilation and depressed cardiac performance in the absence of hypertension, valvular, congenital, or ischemic heart diseases, and which may be related to infection, autoimmune or metabolic abnormalities, or family inheritance. It can progress into congestive heart failure with a poor prognosis. Doxorubicin (Dox) is widely employed as a chemotherapeutic drug, but its use is limited because it causes DCM-like changes of the myocardium. Its myocardial toxicity is attributed to oxidative stress, chronic inflammation, and cardiomyocyte apoptosis. A model of DCM exploiting these Dox-induced DCM symptoms has not been established.

• Authors: Yihai Liu, Wenfeng Zhang, Tingting Hu, Jie Ni, Biao Xu, Wei Huang
• Journal: Journal of visualized experiments : JoVE (J Vis Exp) Issue 159 (05 16 2020) ISSN: 1940-087X [Electronic] United States
• PMID: 32478722 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Video-Audio Media)

Chemical References

• Doxorubicin

Topics

• Animals
• Apoptosis (drug effects)
• Cardiomyopathy, Dilated (chemically induced)
• Disease Models, Animal
• Doxorubicin (adverse effects)
• Male
• Mice, Inbred C57BL
• Myocytes, Cardiac (drug effects)
• Oxidative Stress (drug effects)