Effects of dipeptidyl peptidase-4 inhibitor linagliptin versus sulphonylurea glimepiride on systemic haemodynamics in overweight patients with type 2 diabetes: A secondary analysis of an 8-week, randomized, controlled, double-blind trial.

Abstract

AIM:

To determine the glucose-independent effect of the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin versus the sulphonylurea glimepiride on systemic haemodynamics in the fasting and postprandial state in patients with type 2 diabetes (T2D).

MATERIALS AND METHODS:

In this prespecified secondary analysis of a phase IV, double-blind trial, 46 metformin-treated, overweight patients with T2D were included and randomly assigned (1:1) to once-daily linagliptin (5 mg) or glimepiride (1 mg) for 8 weeks. In a sub-study involving 26 patients, systemic haemodynamics were also assessed following a standardized liquid meal (Nutridrink Yoghurt style). Systemic haemodynamics (oscillometric device and finger photoplethysmography), arterial stiffness (applanation tonometry) and cardiac sympathovagal balance (heart rate variability [HRV]) were measured in the fasting state and repetitively following the meal. Ewing tests were performed in the fasting state.

RESULTS:

From baseline to week 8, linagliptin compared with glimepiride did not affect systemic haemodynamics, arterial stiffness or HRV in the fasting state. Linagliptin increased parasympathetic nervous activity, as measured by the Valsalva manoeuvre (P = .021) and deep breathing test (P = .027) compared with glimepiride. Postprandially, systolic blood pressure (SBP) dropped an average of 7.6 ± 1.6 mmHg. Linagliptin reduced this decrease to 0.7 ± 2.3 mmHg, which was significant to glimepiride (P = .010).

CONCLUSIONS:

When compared with glimepiride, linagliptin does not affect fasting blood pressure. However, linagliptin blunted the postprandial drop in SBP, which could benefit patients with postprandial hypotension.

• Authors: Jordan Kraaijenhof, Marcel H A Muskiet, Lennart Tonneijck, D Margriet Ouwens, Mark H H Kramer, Daniël H van Raalte, Mark M Smits
• Journal: Diabetes, obesity & metabolism (Diabetes Obes Metab) Vol. 22 Issue 10 Pg. 1847-1856 (10 2020) ISSN: 1463-1326 [Electronic] England
• PMID: 32476255 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.

Chemical References

• Blood Glucose
• Dipeptidyl-Peptidase IV Inhibitors
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Sulfonylurea Compounds
• Linagliptin
• glimepiride
• Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

Topics

• Blood Glucose
• Diabetes Mellitus, Type 2 (complications, drug therapy)
• Dipeptidyl-Peptidase IV Inhibitors (therapeutic use)
• Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
• Double-Blind Method
• Glycated Hemoglobin
• Hemodynamics
• Humans
• Hypoglycemic Agents (therapeutic use)
• Linagliptin (therapeutic use)
• Overweight (complications)
• Sulfonylurea Compounds
• Treatment Outcome