Abstract | BACKGROUND: In the most cases of oral squamous cell carcinoma (OSCC), oral epithelial dysplasia (OED) is found adjacent to the primary tumor. The delineation of surgical margins for OSCC is critical to minimize the risk for local recurrence. The aim of this study is to demonstrate that the fluorescence visualization (FV)- device can delineated the lesion visualizes OED of adjacent primary tumors by histopathologically comparison to conventional iodine vital staining. MATERIAL AND METHODS: RESULTS:
Cytokeratin 13 (CK13) expression rate in the area of fluorescence visualization loss (FVL) was significantly lower than that in the area of fluorescence visualization retention (FVR). In addition, CK17, Ki-67, and p53 expression rates were significantly higher in FVL than FVR. There was no significant difference in the delineation rate or area between FVL and iodine-unstained area. High-grade dysplasia was observed most frequently at the FV and iodine-unstained boundary, but no significant pathological differences were found. CONCLUSION: We strongly suggest the FV-guided surgery is a useful method for accurate resection in early-stage tongue squamous cell carcinoma.
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Authors | Yusuke Ikeda, Taiki Suzuki, Hirokazu Saitou, Satoru Ogane, Kazuhiko Hashimoto, Nobuo Takano, Takeshi Nomura |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 25
Issue 9
Pg. 1604-1611
(Sep 2020)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 32451767
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- KRT13 protein, human
- Keratin-13
- Iodine
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Topics |
- Aged
- Biomarkers, Tumor
(metabolism)
- Female
- Fluorescence
- Humans
- Iodine
- Keratin-13
(metabolism)
- Male
- Middle Aged
- Mouth Neoplasms
(pathology)
- Neoplasm Recurrence, Local
- Oral Surgical Procedures
(instrumentation, methods)
- Squamous Cell Carcinoma of Head and Neck
(diagnostic imaging, pathology, surgery)
- Staining and Labeling
- Tongue Neoplasms
(diagnostic imaging, pathology, surgery)
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