Pivotal role of CD103 in the development of psoriasiform dermatitis.

Abstract

The integrin αE known as CD103 binds integrin β7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is mainly expressed by lymphocytes within epithelial tissues of intestine, lung, and skin as well as subsets of mucosal and dermal conventional dendritic cells (cDCs). CD103 has been originally implicated in the attachment of lymphocytes to epithelium in the gut and skin through the interaction with E-cadherin expressed on intestinal epithelial cells, keratinocytes, and Langerhans cells (LCs). However, an impact of CD103 on the cutaneous immune responses and the development of inflammatory skin diseases remains elusive. Here, we report that CD103 regulates the development of psoriasiform dermatitis through the control of the function of cDCs. Deficiency in CD103 exacerbates psoriasiform dermatitis, accompanied by excessive epidermal hyperplasia and infiltration of inflammatory leukocytes. Furthermore, deficiency in CD103 not only accelerates the production of proinflammatory cytokines in psoriatic lesions but also promotes the generation of lymphocytes producing interleukin (IL)-17 in the skin-draining peripheral lymph nodes (PLNs). Under the deficiency in CD103, cDCs localized in PLNs enhance cytokine production following activation. Thus, our findings reveal a pivotal role for CD103 in the control of the function of cDCs to regulate cutaneous inflammation in psoriasiform dermatitis.

• Authors: Takehito Fukui, Tomohiro Fukaya, Tomofumi Uto, Hideaki Takagi, Junta Nasu, Noriaki Miyanaga, Yotaro Nishikawa, Haruhiko Koseki, Narantsog Choijookhuu, Yoshitaka Hishikawa, Yoshihiro Yamashita, Katsuaki Sato
• Journal: Scientific reports (Sci Rep) Vol. 10 Issue 1 Pg. 8371 (05 20 2020) ISSN: 2045-2322 [Electronic] England
• PMID: 32433498 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Integrin alpha Chains
• alpha E integrins

Topics

• Animals
• Antigens, CD (genetics, metabolism)
• Autoimmunity (genetics, physiology)
• Cell Differentiation (genetics, physiology)
• Dermatitis (genetics, metabolism)
• Female
• Flow Cytometry
• Immunohistochemistry
• Integrin alpha Chains (genetics, metabolism)
• Keratinocytes (metabolism)
• Langerhans Cells (metabolism)
• Male
• Mice, Inbred C57BL
• Psoriasis (genetics, metabolism)
• Reverse Transcriptase Polymerase Chain Reaction