The Prognostic Value of Mannose-Binding Lectin in Community-Acquired Pneumonia.

Abstract

Introduction: Community-acquired pneumonia is among the most widespread health issues in the pediatric population, affecting children around the world. Mannose-binding lectin is a component of the innate immune system that binds to carbohydrate fragments expressed by various microorganisms, thus aiding in their recognition and eventually activating the complement system through a specific pathway called "the lectin pathway". Materials and methods: 204 pediatric patients whose mannose-binding lectin levels were evaluated at the beginning of infection were included in the study. Results: Mannose-binding lectin deficit was observed Conclusion: This study makes use of the relevant literature and tackles somewhat controversial aspects, as mannose-binding lectin deficit is classified as a fairly common disturbance of the immune system. For a comprehensive understanding of mannose-binding lectin role in infectious diseases, it is necessary to take into account even contextual factors.

• Authors: Roxana Taras, Georgiana Capitanescu, Marcela Ionescu, Eliza Cinteza, Mihaela Balgradean
• Journal: Maedica (Maedica (Bucur)) Vol. 15 Issue 1 Pg. 11-17 (Mar 2020) ISSN: 1841-9038 [Print] Romania
• PMID: 32419855 (Publication Type: Editorial)