Abstract | OBJECTIVES: METHODS: Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in- stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. RESULTS: In- stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values (p < 0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p < 0.001) were independently associated with six-month in- stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in- stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in- stent restenosis. CONCLUSIONS: Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.
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Authors | Songlin Guo, Zhang Zhang, Lei Wang, Liangxi Yuan, Junmin Bao, Jian Zhou, Zaiping Jing |
Journal | Vascular
(Vascular)
Vol. 28
Issue 6
Pg. 715-721
(Dec 2020)
ISSN: 1708-539X [Electronic] England |
PMID | 32408853
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- IL6 protein, human
- Interleukin-6
- C-Reactive Protein
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Topics |
- Aged
- Aged, 80 and over
- Angioplasty
(adverse effects, instrumentation)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Female
- Femoral Artery
(diagnostic imaging, physiopathology)
- Humans
- Interleukin-6
(blood)
- Male
- Middle Aged
- Peripheral Arterial Disease
(blood, diagnostic imaging, physiopathology, therapy)
- Popliteal Artery
(diagnostic imaging, physiopathology)
- Predictive Value of Tests
- Prospective Studies
- Recurrence
- Risk Assessment
- Risk Factors
- Stents
- Time Factors
- Treatment Outcome
- Vascular Patency
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