Abstract | PURPOSE: METHODS: We retrospectively reviewed the medical records of patients who had surgically resected breast cancer to collect AR expression data and other clinicopathological data. The optimal cut-off for AR positivity was determined using a receiver operating characteristic curve analysis. RESULTS: We reviewed 957 patients with surgically resected breast cancer from June 2012 to April 2013. The median follow-up was 62 months, and relapse events occurred in 101 (10.6%) patients. Unlike the cut-off value of 1% or 10% in previous reports, 35% was determined to be best for predicting relapse-free survival (RFS) in this study. At the cut-off value of 35%, 654 (68.4%) patients were AR-positive. AR expression was more prevalent in luminal A (87.6%) and luminal B (73.1%) types than in human epidermal growth factor receptor 2-positive (56.2%) or triple-negative (20.6%) types. AR expression of ≥ 35% was significantly related to longer RFS in a multivariate analysis (hazard ratio, 0.430; 95% confidence interval, 0.260-0.709; p = 0.001). CONCLUSION: We propose a cut-off value of 35% to best predict RFS in patients with surgically resected breast cancer. AR expression was positive in 68.4% of patients, and AR positivity was found to be an independent prognostic factor for longer RFS.
|
Authors | Yaewon Yang, Ahrum Min, Kyung-Hun Lee, Han Suk Ryu, Tae-Yong Kim, Go-Un Woo, Koung Jin Suh, Dae-Won Lee, Han-Byoel Lee, Hyeong-Gon Moon, Wonshik Han, In Ae Park, Dong-Young Noh, Seock-Ah Im |
Journal | Journal of breast cancer
(J Breast Cancer)
Vol. 23
Issue 2
Pg. 182-193
(04 2020)
ISSN: 1738-6756 [Print] Korea (South) |
PMID | 32395377
(Publication Type: Journal Article)
|
Copyright | © 2020 Korean Breast Cancer Society. |