Estimating a normal reference range for serum B-cell maturation antigen levels for multiple myeloma patients.

Abstract

The serum B-cell maturation antigen (sBCMA) has been identified as a novel serum biomarker for patients with multiple myeloma. However, no study has yet established a reference range for sBCMA levels. Its levels were determined in 196 healthy subjects and showed a right-tailed distribution with a median value of 37·51 ng/ml with a standard deviation of 22·54 ng/ml (range 18·78-180·39 ng/ml). Partitioning of subgroup reference ranges was considered but determined to be irrelevant. A non-parametric method using the median ± 2 standard deviations suggests using a universal reference interval of <82·59 ng/ml.

• Authors: Scott Jew, Sean Bujarski, Camilia Soof, Haiming Chen, Tahmineh Safaie, Mingjie Li, Eric Sanchez, Cathy Wang, Marsiye Emamy-Sadr, Regina Swift, Ashkon Rahbari, Saurabh Patil, Eric Souther, Tanya M Spektor, James R Berenson
• Journal: British journal of haematology (Br J Haematol) Vol. 192 Issue 6 Pg. 1064-1067 (03 2021) ISSN: 1365-2141 [Electronic] England
• PMID: 32321191 (Publication Type: Journal Article)
• Copyright: © 2020 British Society for Haematology and John Wiley & Sons Ltd.

Chemical References

• B-Cell Maturation Antigen
• Biomarkers, Tumor
• Neoplasm Proteins
• TNFRSF17 protein, human

Topics

• Adult
• Aged
• B-Cell Maturation Antigen (blood)
• Biomarkers, Tumor (blood)
• Female
• Humans
• Male
• Middle Aged
• Multiple Myeloma (blood)
• Neoplasm Proteins (blood)