Abstract | INTRODUCTION: METHODS: Pharmacological inhibitors ( Nu9056, L002) of histone acetyltransferases targeting acetylated H4K5 were used to test whether increased acetylated H4K5 was responsible for the impaired differentiation seen in emerin-deficient myogenic progenitors. RESULTS: DISCUSSION: We conclude that emerin regulation of HDAC3 activity to affect H4K5 acetylation dynamics is important for myogenic differentiation. Targeting H4K5ac dynamics represents a potential new strategy for ameliorating the skeletal muscle wasting seen in EDMD1.
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Authors | Katherine A Bossone, Joseph A Ellis, James M Holaska |
Journal | Muscle & nerve
(Muscle Nerve)
Vol. 62
Issue 1
Pg. 128-136
(07 2020)
ISSN: 1097-4598 [Electronic] United States |
PMID | 32304242
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2020 Wiley Periodicals, Inc. |
Chemical References |
- 1,2-bis(isothiazol-5-yl)disulfane
- Thiazoles
- Histone Acetyltransferases
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Topics |
- Animals
- Cell Differentiation
(drug effects, physiology)
- Cells, Cultured
- Histone Acetyltransferases
(antagonists & inhibitors, metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Muscular Dystrophy, Emery-Dreifuss
(drug therapy, pathology)
- Stem Cells
(drug effects, pathology)
- Thiazoles
(pharmacology, therapeutic use)
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