Serial serologic changes of hepatitis D virus in chronic hepatitis B patients receiving nucleos(t)ides analogues therapy.

Abstract

BACKGROUND AND AIM:

The serial serologic changes of hepatitis D virus (HDV) infection among chronic hepatitis B virus (HBV) infected patients who received oral nucleotide/nucleoside analogues are elusive.

METHODS:

Serum anti-HDV and HDV RNA among chronic hepatitis B (CHB) patients were tested at the time of initiating anti-HBV therapy and subsequently during the follow-up period.

RESULTS:

The seropositive rate of anti-HDV and HDV RNA among 2850 CHB patients, was 2.7% and 0.9%, respectively. Factors associated with anti-HDV seropositivity were platelet counts (odds ratio [OR]/95% confidence intervals [CI]: 0.995/0.992-0.999; P = 0.006), HBV DNA levels (OR/CI: 0.81/0.70-0.94; P = 0.005), and hepatitis B e-antigen (HBeAg) seropositivity (OR/CI: 0.22/0.05-0.95; P = 0.04). The only factor associated with HDV RNA positivity among anti-HDV seropositive patients was age (OR/CI: 0.95/0.90-1.00; P = 0.03). The spontaneous clearance rate of serum anti-HDV antibody was 3.0 per 100 person-years with a median follow-up period of 3.5 years (range 2-12 years), whereas the seroclearance rate of HDV RNA was 4.3 per 100 person-years among anti-HDV seropositive patients after a median follow-up period of 6.0 years (range 2-11 years). A baseline anti-HDV titer < 0.5 cut-off index was the only factor predictive of anti-HDV seroclearance (hazard ratio [HR]/CI: 30.11/3.73-242.85; P = 0.001).

CONCLUSIONS:

HDV infection was not common among patients treated for HBV in Taiwan. Seroclearance of anti-HDV and HDV RNA did occur over time, albeit the chance is rare.

• Authors: Tyng-Yuan Jang, Yu-Ju Wei, Cheng-Ting Hsu, Po-Yao Hsu, Ta-Wei Liu, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Yu-Min Ko, Yi-Shan Tsai, Kuan-Yu Chen, Ching-Chih Lin, Pei-Chien Tsai, Shu-Chi Wang, Ching-I Huang, Ming-Lun Yeh, Zu-Yau Lin, Shinn-Cherng Chen, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Chung-Feng Huang, Ming-Lung Yu
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 35 Issue 11 Pg. 1886-1892 (Nov 2020) ISSN: 1440-1746 [Electronic] Australia
• PMID: 32247291 (Publication Type: Journal Article)
• Copyright: © 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

Chemical References

• Antibodies, Viral
• Nucleosides
• RNA, Viral

Topics

• Administration, Oral
• Age Factors
• Antibodies, Viral (blood)
• Coinfection (diagnosis, virology)
• Female
• Follow-Up Studies
• Hepatitis B, Chronic (drug therapy, virology)
• Hepatitis D (diagnosis, virology)
• Hepatitis Delta Virus (genetics, immunology)
• Humans
• Male
• Middle Aged
• Nucleosides (administration & dosage, analogs & derivatives)
• RNA, Viral (blood)
• Serologic Tests
• Taiwan
• Time Factors