Polymorphism -509C/T in TGFB1 Promoter Is Associated With Increased Risk and Severity of Persistent Allergic Rhinitis in a Chinese Population.

Abstract

BACKGROUND:

Polymorphism -509C/T in the promoter of transforming growth factor beta1 (TGFB1) gene is implicated in the pathogenesis of asthma. This polymorphism might also act to regulate the development of allergic rhinitis (AR).

OBJECTIVES:

To investigate whether -509C/T is associated with AR susceptibility and severity in a Han Chinese population.

METHODS:

The study enrolled 263 patients with persistent AR and 249 healthy controls. AR patients were classified as mild or moderate/severe AR groups according to the Allergic Rhinitis and its Impact on Asthma classification. TGFB1 gene polymorphism -509C/T was genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum total Immunoglobulin E (IgE) and specific IgE levels were determined using an ImmunoCAP.

RESULTS:

Significant difference was found in the allele frequency of TGFB1 -509C/T between AR patients and healthy controls (P = .027) but not in the genotype frequency (P =.051). However, the genotype frequency of TGFB1 -509C/T showed significant difference between the mild AR group, the moderate/severe AR group, and the control group (P = .012); between the moderate/severe AR group and the control group (P =.036); between the mild AR group and the moderate/severe AR group (P = .038); but not between the mild AR group and the control group (P =.075).

CONCLUSION:

TGFB1 promoter polymorphism -509C/T may be associated with the susceptibility and the severity of persistent AR of Han Chinese, but the functional relationship still needs clarification.

• Authors: Xin-Jie Zhu, Mei-Ping Lu, Ruo-Xi Chen, Dong-Yun Bu, Lu-Ping Zhu, Mei-Lin Wang, Min Yin, Zheng-Dong Zhang, Lei Cheng
• Journal: American journal of rhinology & allergy (Am J Rhinol Allergy) Vol. 34 Issue 5 Pg. 597-603 (Sep 2020) ISSN: 1945-8932 [Electronic] United States
• PMID: 32216462 (Publication Type: Journal Article)

Chemical References

• TGFB1 protein, human
• Transforming Growth Factor beta1

Topics

• Case-Control Studies
• China
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Polymorphism, Genetic
• Polymorphism, Single Nucleotide
• Rhinitis, Allergic (genetics)
• Transforming Growth Factor beta1 (genetics)