[A Case of Non-Resectable Pancreatic Cancer with Multiple Hepatic Metastases Treated with FOLFIRINOX Therapy and Conversion Surgery].

Abstract

A 50-year-old woman was diagnosed as having pancreatic head cancer with multiple hepatic metastases. FOLFIRINOX therapy was initiated. After completing 18 courses of therapy, partial remission(PR)was achieved based on images, and surgery was then planed. The subtotal stomach-preserving pancreaticoduodenectomy and hepatic S7 partial resection were performed. Macroscopically, complete resection was achieved. Regarding pathological findings of the primary lesion and hepatic metastatic lesions, fibrous formation and hyalinizing condition induced by chemotherapy were noted; moreover, complete disappearance of cancer cells was detected. However, metastasis of poorly differentiated adenocarcinoma was detected in 12b lymph node tissue. One month after the surgery, postoperative adjunctive chemotherapy with S-1 was initiated. However, new hepatic metastasis was detected 3 months after the surgery. Although recurrence treatment was initiated, the disease progressed, and the patient died 11 months after the surgery.

• Authors: Takanobu Akaishi, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Tadashi Odagiri, Hiroaki Fujita, Yu Chen, Kensuke Saito, Takenori Takahata, Atsushi Sato, Kenichi Hakamada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 46 Issue 13 Pg. 2551-2553 (Dec 2019) ISSN: 0385-0684 [Print] Japan
• PMID: 32156995 (Publication Type: Case Reports, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols
• Female
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Middle Aged
• Neoplasm Recurrence, Local
• Pancreatic Neoplasms (drug therapy, surgery)
• Pancreaticoduodenectomy