Highly efficient photocontrolled targeted delivery of siRNA by a cyclodextrin-based supramolecular nanoassembly.

Abstract

In this study, we have constructed a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group. This nanoassembly can bind with siRNA through electrostatic interactions and efficiently delivered them into cancer cells and inhibited their growth.

• Authors: Feng-Qing Li , Qi-Lin Yu , Yao-Hua Liu , Hua-Jiang Yu , Yong Chen , Yu Liu
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 56 Issue 27 Pg. 3907-3910 (Apr 07 2020) ISSN: 1364-548X [Electronic] England
• PMID: 32142087 (Publication Type: Journal Article)

Chemical References

• Imidazoles
• RNA, Small Interfering
• alpha-Cyclodextrins
• Hyaluronic Acid
• Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)
• alpha-cyclodextrin

Topics

• A549 Cells
• Cell Proliferation (drug effects)
• Cell Survival (drug effects)
• Gene Transfer Techniques
• Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) (genetics)
• HEK293 Cells
• Humans
• Hyaluronic Acid (administration & dosage, chemistry, radiation effects)
• Imidazoles (administration & dosage, chemistry, radiation effects)
• Light
• RNA, Small Interfering (administration & dosage, chemistry, radiation effects)
• alpha-Cyclodextrins (administration & dosage, chemistry, radiation effects)