azobenzene

photosensor molecule known to undergo reversible isomerization from trans to cis on illumination with photons of appropriate wavelength; RN given refers to cpd without isomeric designation; structure

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Networked: 136 relevant articles (1 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhao, Yanjun: 5 articles (01/2022 - 07/2019)
2.	Gahl, Cornelius: 5 articles (12/2017 - 10/2012)
3.	Weinelt, Martin: 5 articles (12/2017 - 10/2012)
4.	He, Yaning: 4 articles (01/2022 - 07/2019)
5.	Wang, Zheng: 4 articles (01/2022 - 07/2019)
6.	Kramer, Richard H: 4 articles (01/2020 - 10/2016)
7.	Moldt, Thomas: 4 articles (12/2017 - 01/2015)
8.	Shao, Kuanchun: 3 articles (01/2022 - 04/2020)
9.	Dai, Peipei: 3 articles (11/2020 - 07/2019)
10.	Liu, Fang: 3 articles (11/2020 - 07/2019)

Related Diseases

1.	Photophobia (Light Sensitivity) 03/17/2014 - "We now show how an OR can be combined with a synthetic azobenzene photoswitch to gain light sensitivity. " 10/05/2016 - "Azobenzene photoswitches confer light sensitivity onto retinal ganglion cells (RGCs) in blind mice, making these compounds promising candidates as vision-restoring drugs in humans with degenerative blindness. " 11/18/2021 - "Here, we screen a library of azobenzene photoswitches and identify a urea-substituted "azobenzene-400" core that offers bistable switching between cis and trans with improved kinetics, light sensitivity, and a red-shift. " 10/01/2015 - "Optogenetic gene therapies are in development, but, to date, have suffered from the low light sensitivity of microbial opsins, such as channelrhodopsin and halorhodopsin, and azobenzene-based photoswitches. "
2.	Hypoxia (Hypoxemia) 07/01/2021 - "The results of multiple studies have led to the development of light/hypoxia-responsive azobenzene for biomedical use. " 11/30/2020 - "In this study, a hypoxia-sensitive PEG-azobenzene-PEI-DOPE (PAPD) construct, with an azobenzene group as a hypoxia-sensitive moiety, was prepared. " 01/01/2023 - "Once the drug reached fibroblastic foci, the azobenzene group acted as a hypoxia-responsive linker to trigger effective and rapid drug release. " 01/01/2023 - "Meantime, the hypoxia-responsive azobenzene group allowed for efficient and rapid drug diffusion, while the PEGylated BSA reduced system toxicity and increased circulation in vivo. " 01/01/2022 - "The proposed construct developed, PAPD, contains an azobenzene group as a hypoxia-sensitive moiety that triggers the shedding of the PEG layer from the nanoparticle surface under conditions of hypoxia to improve cellular uptake. "
3.	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 01/07/2020 - "The goal of this study is the improvement of photoswitchable azobenzene glyco-SAMs. " 10/04/2017 - "In a first-principles study based on many-body perturbation theory, we analyze the optical excitations of azobenzene-functionalized self-assembled monolayers (SAMs) with increasing packing density and different terminations, considering for comparison the corresponding gas-phase molecules and dimers. " 05/08/2019 - "Photoisomerization of a series of custom-designed, azobenzene-substituted alkanethiolate (AT) self-assembled monolayers (SAMs) on Au(111) substrates was studied in the context of work function variation, using Kelvin probe measurements as a transduction technique. " 12/06/2017 - "Delocalized versus localized excitations in the photoisomerization of azobenzene-functionalized alkanethiolate SAMs." 10/04/2017 - "Our results suggest that a tailored design of azobenzene-functionalized SAMs which optimizes the interplay between the packing density of the chromophores and their termination can lead to significant improvements in the photo-switching efficiency of these systems."
4.	Carcinogenesis 12/01/1952 - "Catalase studies on rats during p-dimethylamino azobenzene carcinogenesis." 12/01/1998 - "Carcinogenesis was initiated in intestinal lumen of male rats with 7,12,dimethyl benzanthracene, dimethyl amino-methyl azobenzene and 3-methyl cholenthrene. " 12/01/1971 - "Influence of some nitrofurans on carcinogenesis in rats fed 4-(dimethylamino) azobenzene." 06/01/2000 - "To clarify the mechanism of carcinogenesis by azobenzene and hydrazobenzene, we investigated DNA damage induced by hydrazobenzene, using 32P-5'-end-labeled DNA fragments obtained from the c-Ha-ras-1 protooncogene and the p53 tumor suppressor gene. " 05/15/1972 - "[Influence exerted by 2 steroid alkaloids, funtumine and irehdiamine A, on hepato-carcinogenesis induced in the rat with p-dimethylamino-azobenzene (DAB)]."
5.	Neoplasms (Cancer) 01/01/2023 - "Here we show that photoswitching an amphiphilic azobenzene can trigger its intercalation into the plasma membrane of various mammalian cells ranging from erythrocytes to myoblasts and cancer cells. " 05/25/2017 - "Therefore, our results indicate that Si-Azo-CD-PEG could be utilized as a hypoxic cancer-targeting drug delivery carrier, and further suggest that the azobenzene linker could generally be useful for the construction of hypoxic NQO1-responsive nanomaterials." 01/01/2023 - "After arriving at the tumor site, NPHPaPN deshields the PEG shell in response to hypoxia due to the enzymolysis of azobenzene and thus exposes HA. " 11/01/2020 - "In this short review, we present our viewpoints on potential solutions to address the following challenges associated with azobenzene-based photoswitchable chemotherapeutic drugs, including poor tissue penetration of light, hypoxia-induced drug degradation in solid tumor and the autonomous cis-trans relaxation." 01/01/2021 - "Under a tumor hypoxic environment, the enzymatic reduction of azobenzene triggered cationic quaternary ammonium converting into anionic carboxylate. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Electrodes (Electrode)
5.	Precision Medicine