Roles of pattern recognition receptors in diabetic nephropathy.

Abstract

Diabetic nephropathy (DN) is currently the most common complication of diabetes. It is considered to be one of the leading causes of end-stage renal disease (ESRD) and affects many diabetic patients. The pathogenesis of DN is extremely complex and has not yet been clarified; however, in recent years, increasing evidence has shown the important role of innate immunity in DN pathogenesis. Pattern recognition receptors (PRRs) are important components of the innate immune system and have a significant impact on the occurrence and development of DN. In this review, we classify PRRs into secretory, endocytic, and signal transduction PRRs according to the relationship between the PRRs and subcellular compartments. PRRs can recognize related pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), thus triggering a series of inflammatory responses, promoting renal fibrosis, and finally causing renal impairment. In this review, we describe the proposed role of each type of PRRs in the development and progression of DN.

• Authors: Zhi-Feng Zhou, Lei Jiang, Qing Zhao, Yu Wang, Jing Zhou, Qin-Kai Chen, Jin-Lei Lv
• Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) 2020 Mar. Vol. 21 Issue 3 Pg. 192-203 ISSN: 1862-1783 [Electronic] China
• PMID: 32133797 (Publication Type: Journal Article, Review)

Chemical References

• Alarmins
• Mannose-Binding Lectin
• Pathogen-Associated Molecular Pattern Molecules
• Receptors, Pattern Recognition
• Serum Amyloid P-Component
• PTX3 protein
• C-Reactive Protein

Topics

• Alarmins (physiology)
• C-Reactive Protein (analysis, physiology)
• Diabetic Nephropathies (etiology)
• Endocytosis
• Humans
• Immunity, Innate
• Mannose-Binding Lectin (physiology)
• Pathogen-Associated Molecular Pattern Molecules
• Receptors, Pattern Recognition (physiology)
• Serum Amyloid P-Component (physiology)
• Signal Transduction