Abstract | OBJECTIVE: METHOD: Male mice aged 4-5 weeks and weighing about 22-35 g in Shanghai Ninth People's Hospital are divided into three groups: sham group, collagenase intracerebral hemorrhage model (cICH + Vehicle) group and collagenase nicotinamide mononucleotide (cICH + NMN) group. Then, the intervention therapy research is carried out. After 24 h, the neurological function, brain edema, hematoma volume, body weight, hemorrhage volume, RNA expression level, apoptosis, inflammatory factors and reactive oxygen species (ROS) content in surrounding tissues of mice are analyzed comprehensively. RESULTS: Compared with the other two groups, nicotinamide mononucleotides in MCAO model have significant effects on improving neurological function, brain edema, inflammatory factors, body weight and cell apoptosis in mice, but have no significant effect on hemorrhage volume and hematoma volume in mice. CONCLUSION:
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Authors | Liang Shu, Xiaolei Shen, Yaxue Zhao, Rong Zhao, Xinwei He, Jiawen Yin, Jingjing Su, Qiang Li, Jianren Liu |
Journal | Saudi journal of biological sciences
(Saudi J Biol Sci)
Vol. 27
Issue 3
Pg. 899-904
(Mar 2020)
ISSN: 1319-562X [Print] Saudi Arabia |
PMID | 32127769
(Publication Type: Journal Article)
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Copyright | © 2019 The Author(s). |