Individualized Positive End-expiratory Pressure and Regional Gas Exchange in Porcine Lung Injury.

Abstract

BACKGROUND:

In acute respiratory failure elevated intraabdominal pressure aggravates lung collapse, tidal recruitment, and ventilation inhomogeneity. Low positive end-expiratory pressure (PEEP) may promote lung collapse and intrapulmonary shunting, whereas high PEEP may increase dead space by inspiratory overdistension. The authors hypothesized that an electrical impedance tomography-guided PEEP approach minimizing tidal recruitment improves regional ventilation and perfusion matching when compared to a table-based low PEEP/no recruitment and an oxygenation-guided high PEEP/full recruitment strategy in a hybrid model of lung injury and elevated intraabdominal pressure.

METHODS:

In 15 pigs with oleic acid-induced lung injury intraabdominal pressure was increased by intraabdominal saline infusion. PEEP was set in randomized order: (1) guided by a PEEP/inspired oxygen fraction table, without recruitment maneuver; (2) minimizing tidal recruitment guided by electrical impedance tomography after a recruitment maneuver; and (3) maximizing oxygenation after a recruitment maneuver. Single photon emission computed tomography was used to analyze regional ventilation, perfusion, and aeration. Primary outcome measures were differences in PEEP levels and regional ventilation/perfusion matching.

RESULTS:

Resulting PEEP levels were different (mean ± SD) with (1) table PEEP: 11 ± 3 cm H2O; (2) minimal tidal recruitment PEEP: 22 ± 3 cm H2O; and (3) maximal oxygenation PEEP: 25 ± 4 cm H2O; P < 0.001. Table PEEP without recruitment maneuver caused highest lung collapse (28 ± 11% vs. 5 ± 5% vs. 4 ± 4%; P < 0.001), shunt perfusion (3.2 ± 0.8 l/min vs. 1.0 ± 0.8 l/min vs. 0.7 ± 0.6 l/min; P < 0.001) and dead space ventilation (2.9 ± 1.0 l/min vs. 1.5 ± 0.7 l/min vs. 1.7 ± 0.8 l/min; P < 0.001). Although resulting in different PEEP levels, minimal tidal recruitment and maximal oxygenation PEEP, both following a recruitment maneuver, had similar effects on regional ventilation/perfusion matching.

CONCLUSIONS:

When compared to table PEEP without a recruitment maneuver, both minimal tidal recruitment PEEP and maximal oxygenation PEEP following a recruitment maneuver decreased shunting and dead space ventilation, and the effects of minimal tidal recruitment PEEP and maximal oxygenation PEEP were comparable.

• Authors: Thomas Muders, Henning Luepschen, Torsten Meier, Andreas Wolfgang Reske, Jörg Zinserling, Stefan Kreyer, Robert Pikkemaat, Enn Maripu, Steffen Leonhardt, Göran Hedenstierna, Christian Putensen, Hermann Wrigge
• Journal: Anesthesiology (Anesthesiology) Vol. 132 Issue 4 Pg. 808-824 (04 2020) ISSN: 1528-1175 [Electronic] United States
• PMID: 32101968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Animals
• Female
• Lung Injury (diagnostic imaging, metabolism, therapy)
• Male
• Positive-Pressure Respiration (methods)
• Pulmonary Gas Exchange (physiology)
• Respiratory Mechanics (physiology)
• Swine
• Tidal Volume (physiology)