The importance of FDG-PET/CT parameters for the assessment of the immune status in advanced HNSCC.

Abstract

OBJECTIVE:

Cancer cells secrete large amounts of lactic acid via aerobic glycolysis. We have shown that lactic acid plays an important role as a proinflammatory and immunosuppressive mediator and promotes tumor progression. Fluorine-18 fluorodeoxyglucose (FDG) uptake detected by positron emission tomography/computed tomography (PET/CT) is considered as a good indicator of aerobic glycolysis in cancer. In this study, we examined the relationships between systemic inflammatory parameters and FDG-PET/CT parameters in advanced head and neck squamous cell carcinoma (HNSCC). Furthermore, we investigated the relationships between FDG-PET/CT parameters and M2-macrophage polarization in HNSCC by assessing the ratio of CD163, a M2-macrophage marker, to CD68, a pan-macrophage marker.

METHODS:

This study included 73 advanced HNSCC patients. We assessed the C-reactive protein (CRP) level, white blood cell (WBC) count, neutrophil count, lymphocyte count, and monocyte count as systemic inflammatory markers. Additionally, we assessed the maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) as FDG-PET/CT parameters.

RESULTS:

The CRP level, WBC count, and neutrophil count were correlated with whole-body FDG-PET/CT parameters. The CD163/CD68 ratio was correlated with SUVmax and SUVmean. Our results suggest that systemic inflammation, which is associated with neutrophils, develops in patients with HNSCC having tumors with a larger volume and increased glucose uptake and that M2-macrophage polarization is promoted in HNSCC with increased glucose uptake, SUVmax, and SUVmean. FDG-PET/CT has the potential to reflect cancer-related chronic inflammation and immunosuppressive conditions in cancer patients.

CONCLUSIONS:

FDG-PET/CT parameters appear to be useful in assessing the immune status in HNSCC.

• Authors: Toshimitsu Ohashi, Kousuke Terasawa, Mitsuhiro Aoki, Takashi Akazawa, Hirofumi Shibata, Bunya Kuze, Takahiko Asano, Hiroki Kato, Tatsuhiko Miyazaki, Masayuki Matsuo, Norimitsu Inoue, Yatsuji Ito
• Journal: Auris, nasus, larynx (Auris Nasus Larynx) Vol. 47 Issue 4 Pg. 658-667 (Aug 2020) ISSN: 1879-1476 [Electronic] Netherlands
• PMID: 32089351 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Antigens, CD
• Antigens, Differentiation, Myelomonocytic
• CD163 antigen
• CD68 antigen, human
• Radiopharmaceuticals
• Receptors, Cell Surface
• Fluorodeoxyglucose F18
• Lactic Acid
• C-Reactive Protein

Topics

• Aged
• Aged, 80 and over
• Antigens, CD (metabolism)
• Antigens, Differentiation, Myelomonocytic (metabolism)
• C-Reactive Protein (metabolism)
• Female
• Fluorodeoxyglucose F18
• Glycolysis
• Head and Neck Neoplasms (blood, diagnostic imaging, metabolism, pathology)
• Humans
• Inflammation (blood, metabolism)
• Lactic Acid (metabolism)
• Leukocyte Count
• Lymphocyte Count
• Macrophages (metabolism)
• Male
• Middle Aged
• Monocytes
• Neutrophils
• Positron Emission Tomography Computed Tomography
• Radiopharmaceuticals
• Receptors, Cell Surface (metabolism)
• Squamous Cell Carcinoma of Head and Neck (blood, diagnostic imaging, metabolism, pathology)