Abstract | BACKGROUND: Previous investigations reveal that BTP2, a store-operated calcium channel blocker, has protective and anti-inflammatory properties in multiple inflammatory diseases. This study investigates whether BTP2 can protect against decompression sickness (DCS) in a rat model. METHODS: BTP2 (2 mg/kg) was administered to male Sprague-Dawley rats 30 min before subjecting them to hyperbaric pressure. Control rats were not treated. After decompression, signs of DCS were examined, and samples of bronchoalveolar lavage fluid and lung tissue were obtained for evaluation. RESULTS: CONCLUSION: The results suggest that BTP2 may has potential as a prophylactic therapy to attenuate DCS-induced injury.
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Authors | Shih-En Tang, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Kun-Lun Huang, Shi-Jye Chu |
Journal | Frontiers in physiology
(Front Physiol)
Vol. 10
Pg. 1616
( 2019)
ISSN: 1664-042X [Print] Switzerland |
PMID | 32082179
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Tang, Liao, Wu, Pao, Huang and Chu. |