Abstract | INTRODUCTION: MATERIAL AND METHODS: This case-control study compares pregnancies affected by intrahepatic cholestasis ( pruritus and bile acid ≥ 10 μmol/L) with low-risk pregnancies managed between December 2006 and December 2014 at a French university hospital center. RESULTS: There were 83 (59.3%) cases of mild cholestasis (10≤ BA ≤39 μmol/L), 46 (32.8%) of moderate cholestasis (40≤ BA ≤99 μmol/L), and 11 (7.9%) of severe cholestasis (BA ≥100 μmol/L). No in utero fetal deaths occurred in the 140 women with cholestasis or the 560 controls analyzed. The rate of respiratory distress syndrome was higher in neonates of women with intrahepatic cholestasis (17.1% vs. 4.6%, P<0.001; crude OR 4.46 (CI95% 2.49-8.03)). This risk was also significant after adjustment for gestational age at birth and mode of delivery, adjusted OR 2.56 (CI95%1.26-5.18). The postpartum hemorrhage rate was twice as high among the case mothers (25% versus 14.1% for controls, P = 0.002). CONCLUSION:
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Authors | Chloé Arthuis, Caroline Diguisto, Henri Lorphelin, Vincent Dochez, Emmanuel Simon, Franck Perrotin, Norbert Winer |
Journal | PloS one
(PLoS One)
Vol. 15
Issue 2
Pg. e0228213
( 2020)
ISSN: 1932-6203 [Electronic] United States |
PMID | 32074108
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Bile Acids and Salts
(analysis)
- Case-Control Studies
- Cholestasis, Intrahepatic
(diagnosis, pathology)
- Female
- Gestational Age
- Hemorrhage
(epidemiology)
- Humans
- Infant
- Infant, Newborn
- Intensive Care Units, Neonatal
- Odds Ratio
- Perinatal Mortality
- Postpartum Period
- Pregnancy
- Pregnancy Outcome
- Respiratory Distress Syndrome, Newborn
(diagnosis)
- Risk Factors
- Severity of Illness Index
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