Background: Non-infectious
uveitis represents a leading cause of
visual impairment, and
inflammation control represents a major priority in tackling visual acuity loss due to complications such as
macular edema; different
immunomodulatory drugs are currently being used, including anti-
TNF-alpha Adalimumab. Methods: This was a monocentric observational study of 18 eyes of 18 patients with non-infectious
uveitis treated with
Adalimumab. The primary endpoint was the control of ocular
inflammation. The secondary endpoints included the study of macular and choroidal thickness and architecture, visual acuity, changes in other treatments, and adverse effects. Results: Ocular
inflammation was controlled at 12 months for 83.3% of patients. Central macular thickness improved from a median of 229.75 µm at baseline to 213 µm at 12 months, while choroidal thickness decreased by 11.54% at the end of the follow-up. A reduction of
vasculitis on
fluorescein angiography and of hyperreflective spots on optical coherence tomography was noted. Visual acuity also improved from 0.51 (logMAR) before treatment to 0.24 at more than 12 months (p = 0.01). A total of 11.1% of patients experienced side effects. Conclusion: Our study confirms the efficacy of
adalimumab for the control of ocular
inflammation, visual acuity preservation, and for
corticosteroid sparing.