Abstract | BACKGROUND: METHODS: The study evaluated levels of both CHI3L1 and CHI3L2, NPTX2, ionized calcium-binding adapter molecule 1 (Iba1), complement component 1q (C1q), glial fibrillary acidic protein (GFAP), and CD44, in the frontal cortex of people who died with an antemortem clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment (MCI), mild/moderate AD (mAD), and severe AD (sAD) using immunoblot and immunohistochemical techniques. RESULTS: CHI3L1-immunoreactive (-ir) astrocyte numbers were increased in the frontal cortex and white matter in sAD compared to NCI. On the other hand, increases in GFAP and Iba1-ir cell numbers were observed in MCI compared to NCI but only in white matter. Western blot analyses revealed significantly lower frontal cortex CHI3L2 levels, whereas CD44 levels were increased in sAD. No significant differences for CHI3L1, GFAP, C1q, and NPTX2 protein levels were detected between clinical groups. Strong significant correlations were found between frontal cortex CHI3L1 and Iba1-ir cell numbers in white matter and CHI3L1 and C1q protein levels in the early stages of the disease. C1q and Iba1, CD44 with CHI3L2, and GFAP protein levels were associated during disease progression. CHI3L1 and Iba1 cell numbers in white matter showed a significant associations with episodic memory and perceptual speed. CONCLUSIONS: White matter CHI3L1 inflammatory response is associated with cognitive impairment early in the onset of AD.
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Authors | Marta Moreno-Rodriguez, Sylvia E Perez, Muhammad Nadeem, Michael Malek-Ahmadi, Elliott J Mufson |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 17
Issue 1
Pg. 58
(Feb 17 2020)
ISSN: 1742-2094 [Electronic] England |
PMID | 32066474
(Publication Type: Journal Article)
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Chemical References |
- CHI3L1 protein, human
- Chitinase-3-Like Protein 1
- Inflammation Mediators
- Nerve Tissue Proteins
- neuronal pentraxin
- C-Reactive Protein
- CHI3L2 protein, human
- Chitinases
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(metabolism, pathology)
- C-Reactive Protein
(analysis, metabolism)
- Chitinase-3-Like Protein 1
(analysis, metabolism)
- Chitinases
(analysis, metabolism)
- Disease Progression
- Female
- Frontal Lobe
(metabolism, pathology)
- Humans
- Inflammation Mediators
(analysis, metabolism)
- Male
- Nerve Tissue Proteins
(analysis, metabolism)
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