Abstract |
Sonodynamic therapy (SDT) is a noninvasive ultrasound-triggered therapeutic strategy for site-specific treatment of tumors with great depth penetration. The design of nano-sonosensitizers suitable for SDT treatment of bladder cancer (BCa) post- intravesical instillation has not yet been reported. Herein, a transmucosal oxygen-self-production SDT nanoplatform is developed to achieve highly efficient SDT against BCa. In this system, fluorinated chitosan (FCS) is synthesized as a highly effective nontoxic transmucosal delivery carrier to assemble with meso-tetra(4-carboxyphenyl)porphine-conjugated catalase (CAT- TCPP). The formed CAT- TCPP/FCS nanoparticles after intravesical instillation into the bladder cavity exhibit excellent transmucosal and intratumoral penetration capacities and could efficiently relieve hypoxia in tumor tissues by the catalase-catalyzed O2 generation from tumor endogenous H2O2 to further improve the therapeutic efficacy of SDT to ablate orthotopic bladder tumors under ultrasound. Our work presents a nano-sonosensitizer formulation with FCS to enhance transmucosal delivery and intratumoral diffusion and CAT to improve tumor oxygenation, promising for instillation-based SDT to treat bladder tumors without the concern of systemic toxicity.
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Authors | Guangzhi Li, Shupeng Wang, Dashi Deng, Zhisheng Xiao, Ziliang Dong, Zhiping Wang, Qifang Lei, Shan Gao, Guixiao Huang, Enpu Zhang, Guohua Zeng, Zhong Wen, Song Wu, Zhuang Liu |
Journal | ACS nano
(ACS Nano)
Vol. 14
Issue 2
Pg. 1586-1599
(02 25 2020)
ISSN: 1936-086X [Electronic] United States |
PMID | 32011860
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Porphyrins
- tetracarboxyphenylporphine
- Chitosan
- Catalase
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Topics |
- Administration, Intravesical
- Animals
- Catalase
(chemistry, metabolism)
- Cell Line, Tumor
- Chitosan
(administration & dosage, chemistry, metabolism)
- Drug Delivery Systems
- Halogenation
- Mice
- Molecular Structure
- Nanoparticles
(administration & dosage, chemistry, metabolism)
- Particle Size
- Photosensitizing Agents
(chemistry, metabolism, therapeutic use)
- Porphyrins
(chemistry, metabolism, therapeutic use)
- Surface Properties
- Ultrasonic Therapy
- Urinary Bladder Neoplasms
(drug therapy, metabolism)
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